ArticleAdvances in chronic kidney disease2011
Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system.
Article in Advances in chronic kidney disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma.British journal of cancer · 2019Trial
- A Phase 1 study of ARQ 087, an oral pan-FGFR inhibitor in patients with advanced solid tumours.British journal of cancer · 2017Trial
- The Impact of Hyperphosphatemia on Mineral and Bone Metabolism: Implications for Bone and Vascular Health.International journal of molecular sciences · 2026Review
- Tasurgratinib in patients with cholangiocarcinoma or gastric cancer: Expansion part of the first-in-human phase I study.Cancer science · 2025Article
- Sugar sweetened beverage consumption is positively associated with Klotho levels at two years of age in LatinX youth.BMC nutrition · 2021Article
- FGF/FGFR Signaling in Hepatocellular Carcinoma: From Carcinogenesis to Recent Therapeutic Intervention.Cancers · 2021Review
- Associated factors related to chronic kidney disease progression in elderly patients.PloS one · 2019Observational
- A comparative review of use of sulphate and phosphate salts for colonoscopy preparations and their potential for nephrotoxicity.Endoscopy international open · 2018Review
- Intestinal Phosphorus Absorption in Chronic Kidney Disease.Nutrients · 2018Review
- Aging and sex affect soluble alpha klotho levels in bonobos and chimpanzees.Frontiers in zoology · 2018Article
- The age-related changes of dietary phosphate responsiveness in plasma 1,25-dihydroxyvitamin D levels and renal Cyp27b1 and Cyp24a1 gene expression is associated with renal α-Klotho gene expression in mice.Journal of clinical biochemistry and nutrition · 2018Article
- The role of Klotho in energy metabolism.Nature reviews. Endocrinology · 2012Review
- Vitamin D safety and requirements.Archives of biochemistry and biophysics · 2012Review
- Osteo-renal regulation of systemic phosphate metabolism.IUBMB life · 2011Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Phosphorus is an essential nutrient and is routinely assimilated through consumption of food. The body's need of phosphate is usually fulfilled by intestinal absorption of this element from the consumed food, whereas its serum level is tightly regulated by renal excretion or reabsorption. Sodium-dependent phosphate transporters, located in the luminal side of the proximal tubular epithelial cells, have a molecular control on renal phosphate excretion and reabsorption. The systemic regulation of phosphate metabolism is a complex multiorgan process, and the identification of fibroblast growth factor-23 (FGF23)-Klotho system as a potent phosphatonin has provided new mechanistic insights into the homeostatic control of phosphate. Hypophosphatemia as a result of an increase in urinary phosphate wasting after activation of the FGF23-Klotho system is a common phenomenon, observed in both animal and human studies, whereas suppression of the FGF23-Klotho system leads to the development of hyperphosphatemia. This article will briefly summarize how delicate interactions of the FGF23-klotho system can regulate systemic phosphate homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.