ReviewMitochondrion2012
The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration.
Review in Mitochondrion, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Functional expression of mitochondrial KPflugers Archiv : European journal of physiology · 2022Article
- Single-Channel Properties of the ROMK-Pore-Forming Subunit of the Mitochondrial ATP-Sensitive Potassium Channel.International journal of molecular sciences · 2019Article
- Mitochondrial Pharmacology of Dimebon (Latrepirdine) Calls for a New Look at its Possible Therapeutic Potential in Alzheimer's Disease.Aging and disease · 2018Review
- Evaluation of the Mitochondria-Related Redox and Bioenergetics Effects of Gastrodin in SH-SY5Y Cells Exposed to Hydrogen Peroxide.Journal of molecular neuroscience : MN · 2018Article
- Divalent cation chelators citrate and EDTA unmask an intrinsic uncoupling pathway in isolated mitochondria.Journal of bioenergetics and biomembranes · 2017Article
- Ceramide channels and mitochondrial outer membrane permeability.Journal of bioenergetics and biomembranes · 2017Review
- Mitochondrial Ion Channels in Cancer Transformation.Frontiers in oncology · 2015Review
- Sustained mitochondrial functioning in cerebral arteries after transient ischemic stress in the rat: a potential target for therapies.American journal of physiology. Heart and circulatory physiology · 2014Article
- Intracellular ion channels and cancer.Frontiers in physiology · 2013Review
- Modulators of mitochondrial protein import.ACS medicinal chemistry letters · 2013Article
- Cytotoxic and apoptotic effects of different extracts of Artemisia turanica Krasch. on K562 and HL-60 cell lines.TheScientificWorldJournal · 2013Article
- Mitochondrial dysfunction--a pharmacological target in Alzheimer's disease.Molecular neurobiology · 2012Review
- VDAC1: from structure to cancer therapy.Frontiers in oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mitochondria communicate with the rest of the cell through channels located in their inner and outer membranes. Most of the time, the message is encoded by the flow of anions and cations e.g., through VDAC and PTP, respectively. However, proteins are also both imported and exported across the mitochondrial membranes e.g., through TOM and MAC, respectively. Transport through mitochondrial channels is exquisitely regulated and controls a myriad of processes; from energy production to cell death. Here, we examine the role of some of the mitochondrial channels involved in neurodegeneration, ischemia-reperfusion injury and cancer in the context of their potential as therapeutic targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.