ArticleFree radical biology & medicine2011
Nectarine promotes longevity in Drosophila melanogaster.
Article in Free radical biology & medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- In Vivo Effects ofJournal of microbiology and biotechnology · 2023Article
- Transfer of Human Microbiome to Drosophila Gut Model.Microorganisms · 2022Article
- Lampaya Medicinalis Phil. decreases lipid-induced triglyceride accumulation and proinflammatory markers in human hepatocytes and fat body of Drosophila melanogaster.International journal of obesity (2005) · 2021Article
- Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?Biomolecules · 2020Review
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- Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: theGenes & nutrition · 2019Review
- Complex effects of Ayurvedic formulation:Journal of genetics · 2018Article
- The Effects of High Fat Diet-Induced Stress on Olfactory Sensitivity, Behaviors, and Transcriptional Profiling inInternational journal of molecular sciences · 2018Article
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- The odor of a plant metabolite affects life history traits in dietary restricted adult olive flies.Scientific reports · 2016Article
- Global transcriptional dynamics of diapause induction in non-blood-fed and blood-fed Aedes albopictus.PLoS neglected tropical diseases · 2015Article
- Establishment of a comprehensive list of candidate antiaging medicinal herb used in korean medicine by text mining of the classical korean medical literature, "dongeuibogam," and preliminary evaluation of the antiaging effects of these herbs.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Nutraceuticals for geriatrics.Journal of traditional and complementary medicine · 2015Review
- Cranberry interacts with dietary macronutrients to promote healthy aging in Drosophila.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice.Age (Dordrecht, Netherlands) · 2014Article
- Biology of ageing and role of dietary antioxidants.BioMed research international · 2014Review
- The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1.Age (Dordrecht, Netherlands) · 2013Article
- A botanical containing freeze dried açai pulp promotes healthy aging and reduces oxidative damage in sod1 knockdown flies.Age (Dordrecht, Netherlands) · 2013Article
- The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster.Age (Dordrecht, Netherlands) · 2013Article
- Protective effect of borage seed oil and gamma linolenic acid on DNA: in vivo and in vitro studies.PloS one · 2013Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Fruits containing high antioxidant capacities and other bioactivities are ideal for promoting longevity and health span. However, few fruits are known to improve the survival and health span in animals, let alone the underlying mechanisms. Here we investigate the effects of nectarine, a globally consumed fruit, on life span and health span in Drosophila melanogaster. Wild-type flies were fed standard, dietary restriction (DR), or high-fat diet supplemented with 0-4% nectarine extract. We measured life span, food intake, locomotor activity, fecundity, gene expression changes, and oxidative damage indicated by the level of 4-hydroxynonenal-protein adduct in these flies. We also measured life span, locomotor activity, and oxidative damage in sod1 mutant flies on the standard diet supplemented with 0-4% nectarine. Supplementation with 4% nectarine extended life span, increased fecundity, and decreased expression of some metabolic genes, including a key gluconeogenesis gene, PEPCK, and oxidative stress-response genes, including peroxiredoxins, in female wild-type flies fed the standard, DR, or high-fat diet. Nectarine reduced oxidative damage in wild-type females fed the high-fat diet. Moreover, nectarine improved the survival of and reduced oxidative damage in female sod1 mutant flies. Together, these findings suggest that nectarine promotes longevity and health span partly by modulating glucose metabolism and reducing oxidative damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.