ArticleBMC microbiology2011
Comparative genotypic and pathogenic examination of Campylobacter concisus isolates from diarrheic and non-diarrheic humans.
Article in BMC microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive analysis of interleukin-8 gene polymorphisms and periodontitis susceptibility.Oncotarget · 2017Pooled it
- Genetic Diversity ofMicroorganisms · 2025Article
- Campylobacter concisus from chronic inflammatory bowel diseases stimulates IL-8 production in HT-29 cells.Gut pathogens · 2023Article
- Investigation ofFrontiers in microbiology · 2023Article
- Global epidemiology of campylobacteriosis and the impact of COVID-19.Frontiers in cellular and infection microbiology · 2022Review
- High genetic diversity in Campylobacter concisus isolates from patients with microscopic colitis.Gut pathogens · 2021Article
- Population Biology and Comparative Genomics of Campylobacter Species.Current topics in microbiology and immunology · 2021Review
- Development of Bacterial Therapeutics against the Bovine Respiratory Pathogen Mannheimia haemolytica.Applied and environmental microbiology · 2019Article
- [Oral microbiota and inflammatory bowel disease].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2019Review
- Motility and biofilm formation of the emerging gastrointestinal pathogen Campylobacter concisus differs under microaerophilic and anaerobic environments.Gut microbes · 2019Article
- Campylobacter Concisus and Its Effect on the Expression of CDX1 and COX2Asian Pacific journal of cancer prevention : APJCP · 2018Article
- Site-directed mutagenesis of Campylobacter concisus respiratory genes provides insight into the pathogen's growth requirements.Scientific reports · 2018Article
- Genomic analysis of oral Campylobacter concisus strains identified a potential bacterial molecular marker associated with active Crohn's disease.Emerging microbes & infections · 2018Article
- Updating the genomic taxonomy and epidemiology of Campylobacter hyointestinalis.Scientific reports · 2018Article
- Molecular epidemiology and comparative genomics of Campylobacter concisus strains from saliva, faeces and gut mucosal biopsies in inflammatory bowel disease.Scientific reports · 2018Article
- The Growth and Protein Expression of Inflammatory Bowel Disease-AssociatedFrontiers in microbiology · 2018Article
- The Clinical Importance ofFrontiers in cellular and infection microbiology · 2018Review
- Complete Genome Sequence ofGenome announcements · 2017Article
- Azathioprine, Mercaptopurine, and 5-Aminosalicylic Acid Affect the Growth of IBD-AssociatedFrontiers in microbiology · 2017Article
- Article
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2 authors.
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Abstract
backgroundCampylobacter concisus is an emerging enteric pathogen, yet it is commonly isolated from feces and the oral cavities of healthy individuals. This genetically complex species is comprised of several distinct genomospecies which may vary in pathogenic potential.
resultsWe compared pathogenic and genotypic properties of C. concisus fecal isolates from diarrheic and healthy humans residing in the same geographic region. Analysis of amplified fragment length polymorphism (AFLP) profiles delineated two main clusters. Isolates assigned to AFLP cluster 1 belonged to genomospecies A (based on genomospecies-specific differences in the 23S rRNA gene) and were predominantly isolated from healthy individuals. This cluster also contained a reference oral strain. Isolates assigned to this cluster induced greater expression of epithelial IL-8 mRNA and more frequently contained genes coding for the zonnula occludins toxin and the S-layer RTX. Furthermore, isolates from healthy individuals induced greater apoptotic DNA fragmentation and increased metabolic activity than those from diarrheic individuals, and isolates assigned to genomospecies A (of which the majority were from healthy individuals) exhibited higher haemolytic activity compared to genomospecies B isolates. In contrast, AFLP cluster 2 was predominated by isolates belonging to genomospecies B and those from diarrheic individuals. Isolates from this cluster displayed greater mean epithelial invasion and translocation than cluster 1 isolates.
conclusionTwo main genetically distinct clusters (i.e., genomospecies) were identified among C. concisus fecal isolates from healthy and diarrheic individuals. Strains within these clusters differed with respect to clinical presentation and pathogenic properties, supporting the hypothesis that pathogenic potential varies between genomospecies. ALFP cluster 2 isolates were predominantly from diarrheic patients, and exhibited higher levels of epithelial invasion and translocation, consistent with known roles for these factors in diarrhoeal disease. Conversely, isolates from healthy humans and AFLP cluster 1 or genomospecies A (which were predominantly isolated from healthy humans) exhibited increased haemolytic ability, apoptotic DNA fragmentation, IL-8 induction, and/or carriage of toxin genes. Given that this cluster contains an oral reference strain, it is possible that some of the AFLP cluster 1 isolates are periodontal pathogens and may cause disease, albeit via a different mechanism than those from AFLP cluster 2.
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