ArticleBMC endocrine disorders2011
Delayed β-cell response and glucose intolerance in young women with Turner syndrome.
Article in BMC endocrine disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00419107 (Beta Cell Function in Women With Turner Syndrome), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Beta Cell Function in Women With Turner Syndrome
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Global prevalence of autoimmune diseases in turner syndrome: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Clinical practice guidelines for the care of girls and women with Turner syndrome.European journal of endocrinology · 2024Guideline
- Co-occurrence of Gitelman syndrome and turner syndrome: a Case Report and literature review.Frontiers in genetics · 2026Article
- Characterization of Turner Syndrome-associated Diabetes Mellitus.The Journal of clinical endocrinology and metabolism · 2025Article
- Diagnosis of Turner syndrome after presenting with ischemic cardiomyopathy: A case report.SAGE open medical case reports · 2025Article
- Turner Syndrome where are we?Orphanet journal of rare diseases · 2024Review
- Screening for Turner Syndrome-Associated Hyperglycemia: Evaluating Hemoglobin A1c and Fasting Blood Glucose.Hormone research in paediatrics · 2024Article
- Components of the metabolic syndrome in girls with Turner syndrome treated with growth hormone in a long term prospective study.Frontiers in endocrinology · 2023Article
- Hyperglycemia in Turner syndrome: Impact, mechanisms, and areas for future research.Frontiers in endocrinology · 2023Review
- Metabolic consequences of recombinant human growth hormone therapy in patients with Turner syndrome.Pediatric endocrinology, diabetes, and metabolism · 2023Article
- Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome.Archives of endocrinology and metabolism · 2021Article
- Increased Prevalence of Beta-Cell Dysfunction despite Normal HbA1c in Youth and Young Adults with Turner Syndrome.Hormone research in paediatrics · 2021Observational
- Changes in insulin sensitivity and insulin secretion during pregnancy and post partum in women with gestational diabetes.BMJ open diabetes research & care · 2020Article
- Insulin Sensitivity and Pancreatic β-Cell Function in Ecuadorian Women With Turner Syndrome.Frontiers in endocrinology · 2020Article
- Turner syndrome: mechanisms and management.Nature reviews. Endocrinology · 2019Review
- Glucose Metabolism in Turner Syndrome.Frontiers in endocrinology · 2019Review
- New insights on diabetes in Turner syndrome: results from an observational study in adulthood.Endocrine · 2018Observational
- Cardiometabolic and vascular risks in young and adolescent girls with Turner syndrome.BBA clinical · 2015Review
- Insulin resistance in adolescents with Turner syndrome is comparable to obese peers, but the overall metabolic risk is lower due to unknown mechanism.Journal of endocrinological investigation · 2015Article
- Concurrent insulinoma with mosaic Turner syndrome: A case report.Experimental and therapeutic medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate glucose homeostasis in detail in Turner syndrome (TS), where impaired glucose tolerance (IGT) and type 2 diabetes are frequent.
methodsCross sectional study of women with Turner syndrome (TS)(n = 13) and age and body mass index matched controls (C) (n = 13), evaluated by glucose tolerance (oral and intravenous glucose tolerance test (OGTT and IVGTT)), insulin sensitivity (hyperinsulinemic, euglycemic clamp), beta-cell function (hyperglycaemic clamp, arginine and GLP-1 stimulation) and insulin pulsatility.
resultsFasting glucose and insulin levels were similar. Higher glucose responses was seen in TS during OGTT and IVGTT, persisting after correction for body weight or muscle mass, while insulin responses were similar in TS and C, despite the higher glucose level in TS, leading to an insufficient increase in insulin response during dynamic testing. Insulin sensitivity was comparable in the two groups (TS vs. control: 8.6 ± 1.8 vs. 8.9 ± 1.8 mg/kg*30 min; p = 0.6), and the insulin responses to dynamic β-cell function tests were similar. Insulin secretion patterns examined by deconvolution analysis, approximate entropy, spectral analysis and autocorrelation analysis were similar. In addition we found low IGF-I, higher levels of cortisol and norepinephrine and an increased waist-hip ratio in TS.
conclusionsYoung normal weight TS women show significant glucose intolerance in spite of normal insulin secretion during hyperglycaemic clamping and normal insulin sensitivity. We recommend regularly testing for diabetes in TS.
trial registrationRegistered with http://clinicaltrials.com, ID nr: NCT00419107.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.