ArticleACS combinatorial science2011
Boronic acid functionalized peptidyl synthetic lectins: combinatorial library design, peptide sequencing, and selective glycoprotein recognition.
Article in ACS combinatorial science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 49 citations in OpenAlex.
- Affinity on Demand: A One-Pot Method for Synthesis and Sample Enrichment Using TentaGel-Functionalized Resins.ACS omega · 2025Article
- Merging the Versatile Functionalities of Boronic Acid with Peptides.International journal of molecular sciences · 2021Review
- Molecular Boronic Acid-Based Saccharide Sensors.ACS sensors · 2021Review
- Synthesis and Evaluation of Protein-Phenylboronic Acid Conjugates as Lectin Mimetics.ACS omega · 2018Article
- An efficient methodology to introduceNew journal of chemistry = Nouveau journal de chimie · 2017Article
- Nanostructures for the Inhibition of Viral Infections.Molecules (Basel, Switzerland) · 2015Review
- Molecular recognition with boronic acids-applications in chemical biology.Journal of chemical biology · 2013Review
- In situ recognition of cell-surface glycans and targeted imaging of cancer cells.Scientific reports · 2013Article
- Synthetic lectin arrays for the detection and discrimination of cancer associated glycans and cell lines.Chemical science · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Aberrant glycosylation of cell membrane and secreted glycoproteins is a hallmark of various disease states, including cancer. The natural lectins currently used in the recognition of these glycoproteins are costly, difficult to produce, and unstable toward rigorous use. Herein we describe the design and synthesis of several boronic acid functionalized peptide-based synthetic lectin (SL) libraries, as well as the optimized methodology for obtaining peptide sequences of these SLs. SL libraries were subsequently used to identify SLs with as high as 5-fold selectivity for various glycoproteins. SLs will inevitably find a role in cancer diagnostics, given that they do not suffer from the drawbacks of natural lectins and that the combinatorial nature of these libraries allows for the identification of an SL for nearly any glycosylated biomolecule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.