ReviewProtein science : a publication of the Protein Society2011
An alternative view of the proposed alternative activities of hemopexin.
Review in Protein science : a publication of the Protein Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Red Blood Cells in Normal and Pathological States: Redox Reactions of Hemoglobin.Molecules (Basel, Switzerland) · 2026Review
- The association of hemopexin, muscle quality, and sarcopenia in Japanese older adults with cognitive impairment: a cross-sectional study.BMC geriatrics · 2025Article
- Profiling the alterations of serum proteome in dairy cows with retained placenta using high-throughput tandem mass tags quantitative approach.The veterinary quarterly · 2023Article
- Effect of hemopexin treatment on outcome after intracerebral hemorrhage in mice.Brain research · 2021Article
- Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Proteomics.Kidney international reports · 2020Article
- Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis.Molecular medicine (Cambridge, Mass.) · 2016Article
- Blood substitutes: why haven't we been more successful?Trends in biotechnology · 2014Review
- Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies.Cold Spring Harbor perspectives in medicine · 2013Review
- [Anatomical heterogeneity in the proteome of human subcutaneous adipose tissue].Anales de pediatria (Barcelona, Spain : 2003) · 2013Article
- Review
- Renal cortical hemopexin accumulation in response to acute kidney injury.American journal of physiology. Renal physiology · 2012Article
- The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins.Intrinsically disordered proteinsReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Hemopexin is a plasma protein that plays a well-established biological role in sequestering heme that is released into the plasma from hemoglobin and myoglobin as the result of intravascular or extravascular hemolysis as well as from skeletal muscle trauma or neuromuscular disease. In recent years, a variety of additional biological activities have been attributed to hemopexin, for example, hyaluronidase activity, serine protease activity, pro-inflammatory and anti-inflammatory activity as well as suppression of lymphocyte necrosis, inhibition of cellular adhesion, and binding of divalent metal ions. This review examines the challenges involved in the purification of hemopexin from plasma and in the recombinant expression of hemopexin and evaluates the questions that these challenges and the characteristics of hemopexin raise concerning the validity of many of the new activities proposed for this protein. As well, an homology model of the three-dimensional structure of human hemopexin is used to reveal that the protein lacks the catalytic triad that is characteristic of many serine proteases but that hemopexin possesses two highly exposed Arg-Gly-Glu sequences that may promote interaction with cell surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.