Evidence map›Paper›PMID 21404360›Full record

ReviewProtein science : a publication of the Protein Society2011

NMR reveals novel mechanisms of protein activity regulation.

Charalampos G Kalodimos

Open access · bronzeAbstract readReview
In one paragraph

Review in Protein science : a publication of the Protein Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. Integrated Computational Approaches and Tools forAllosteric Drug Discovery.International journal of molecular sciences · 2020
    Review
  4. Article
  5. Review
  6. Article
  7. A Unique and Simple Approach to Improve Sensitivity inMolecules (Basel, Switzerland) · 2017
    Article
  8. Review
  9. NMR Methods to Study Dynamic Allostery.PLoS computational biology · 2016
    Review
  10. Article
  11. Article
  12. Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Charalampos G KalodimosDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, USA. babis@rutgers.edu
Quantitative BioSciences · US

Funding

Structural basis for the assembly of the Sec translocase machineryR01GM073854 · NIGMS · UNIVERSITY OF MINNESOTA · PI KALODIMOS, CHARALAMPOS · 2007 to 2016
$3.1M
Regulatory mechanisms of the Crk Adapter proteinR01GM080308 · NIGMS · UNIVERSITY OF MINNESOTA · PI KALODIMOS, CHARALAMPOS · 2007 to 2015
$2.7M
NIGMS NIH HHS GM073854NIGMS NIH HHS GM080308
6 · The paper itself

Abstract

NMR spectroscopy is one of the most powerful tools for the characterization of biomolecular systems. A unique aspect of NMR is its capacity to provide an integrated insight into both the structure and intrinsic dynamics of biomolecules. In addition, NMR can provide site-resolved information about the conformation entropy of binding, as well as about energetically excited conformational states. Recent advances have enabled the application of NMR for the characterization of supramolecular systems. A summary of mechanisms underpinning protein activity regulation revealed by the application of NMR spectroscopy in a number of biological systems studied in the lab is provided.

Indexed as

Protein ConformationProtein Structure, TertiaryAllosteric RegulationAnimalsHumansMagnetic Resonance SpectroscopyModels, ChemicalModels, MolecularProtein BindingProteinsProteins

Identifiers

PMID21404360
PMCPMC3125862
OpenAlexW2070814101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.