ArticleMolecular and cellular biology1990
Secreted int-1 protein is associated with the cell surface.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 211 citations in OpenAlex.
- Regulation of Wnt distribution and function by Drosophila glypicans.Journal of cell science · 2022Review
- Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons.eLife · 2016Article
- Wnt Signaling in Cell Motility and Invasion: Drawing Parallels between Development and Cancer.Cancers · 2016Review
- Altered expression of cell-cell adhesion molecules β-catenin/E-cadherin and related Wnt-signaling pathway in sporadic and syndromal keratocystic odontogenic tumors.Clinical oral investigations · 2011Article
- Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells.The Journal of biological chemistry · 2010Article
- Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells.Experimental hematology · 2009Article
- Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila.The EMBO journal · 2008Article
- WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer.Molecular biology of the cell · 2007Article
- Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis.BMC immunology · 2006Article
- The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts.Molecular and cellular biology · 2005Article
- The extracellular matrix component WIF-1 is expressed during, and can modulate, retinal development.Molecular and cellular neurosciences · 2004Article
- A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.Molecular and cellular biology · 2003Article
- Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells.BMC developmental biology · 2003Article
- Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Inducible expression of FGF-3 in mouse mammary gland.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex.The Journal of cell biology · 2000Article
- Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.Oncogene · 1999Article
- Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Chimeric Wnt proteins define the amino-terminus of Wnt-1 as a transformation-specific determinant.Oncogene · 1999Article
- High expression of Wnt7b in human superficial bladder cancer vs invasive bladder cancer.British journal of cancer · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The murine int-1 proto-oncogene has been implicated in neural development and, when transcriptionally activated by mouse mammary tumor virus, contributes to the genesis of mammary tumors. To understand the function of the int-1 gene product in these processes, we have characterized the biochemical properties of int-1 protein expressed in a neuroendocrine cell line transfected with int-1 cDNA. Here we provide evidence that int-1 protein is secreted and associates with the cell surface. int-1 protein was very efficiently processed and secreted through the constitutive secretory pathway, although no int-1 protein could be immunoprecipitated from the culture medium. Treatment with suramin effectively released mature int-1 proteins into the culture fluid, which suggests that secreted int-1 protein associates with the cell surface or extracellular matrix. We have also shown directly, by radioiodination of intact cells and by surface antibody adsorption, that secreted int-1 proteins can be detected on the cell surface. These data support a model in which int-1 protein is secreted and functions locally in cell-to-cell signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.