ReviewCurrent psychiatry reports2011
Neurobiology of delusions in Alzheimer's disease.
Review in Current psychiatry reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Neuropsychiatric Inventory domains cluster into neuropsychiatric syndromes in Alzheimer's disease: A systematic review and meta-analysis.Brain and behavior · 2022Pooled it
- Clinical and Structural Differences in Delusions Across Diagnoses: A Systematic Review.Frontiers in integrative neuroscience · 2021Pooled it
- Network localization of heterogeneous neuroimaging findings.Brain : a journal of neurology · 2019Pooled it
- Delusions in Parkinson's Disease: A Systematic Review of Published Cases.Neuropsychology review · 2018Pooled it
- Clinical Heterogeneity in Alzheimer's Disease: A Possible New Amnesic Phenotype.Journal of Alzheimer's disease reports · 2024Review
- Psychosis in Alzheimer disease - mechanisms, genetics and therapeutic opportunities.Nature reviews. Neurology · 2022Review
- Brain Metabolic Dysfunction in Early Neuropsychiatric Symptoms of Dementia.Frontiers in pharmacology · 2019Review
- Understanding the Delusion of Theft.The Psychiatric quarterly · 2018Review
- Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders.Oxidative medicine and cellular longevity · 2018Review
- Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms.Alzheimer's & dementia (New York, N. Y.) · 2017Review
- Neuropsychiatric Symptoms in Mild Cognitive Impairment.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Review
- Transdiagnostic Extension of Delusions: Schizophrenia and Beyond.Schizophrenia bulletin · 2017Review
- Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions.International journal of geriatric psychiatry · 2016Article
- Lewy Bodies, Vascular Risk Factors, and Subcortical Arteriosclerotic Leukoencephalopathy, but not Alzheimer Pathology, are Associated with Development of Psychosis in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2016Article
- Cognitive phenotype of psychotic symptoms in Alzheimer's disease: evidence for impaired visuoperceptual function in the misidentification subtype.International journal of geriatric psychiatry · 2015Article
- Catecholamine-Based Treatment in AD Patients: Expectations and Delusions.Frontiers in aging neuroscience · 2015Review
- Behavioral symptoms related to cognitive impairment.Neuropsychiatric disease and treatment · 2013Review
- Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome.Alzheimer's research & therapy · 2013Review
- Behavioral and psychological symptoms of dementia.Frontiers in neurology · 2012Article
- Othello syndrome-at the interface of neurology and psychiatry.Nature reviews. Neurology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Alzheimer's disease (AD) is associated with cognitive and functional impairment as well as neuropsychiatric sequelae, including psychotic symptoms such as delusions and hallucinations. Strong evidence supports the need to study delusions separate from hallucinations. Integrating the epidemiology, clinical correlates, and neuropathological and genetic literature for delusions in AD allows us to speculate on etiology and mechanisms. Plaque and tangle deposition in individuals with susceptible alleles of serotonergic, muscarinic, nicotinic, or Apoε4 genes appears to result in disruption of cortical circuitry, culminating in delusions. While delusions in AD correspond to a phenotype distinct from AD without delusions, subtypes of delusions may also define further distinct clinical entities. Persecutory delusions may occur earlier in the illness and have a more significant genetic component than misidentification delusions, which are associated with increased cognitive impairment and advanced dementia. Clearly distinguishing between these two syndromes is essential to making progress in the area of delusions in AD.
Indexed as
Identifiers
21404128What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.