ArticleInternational orthopaedics2012
Impact of close surgical margin on local recurrence and survival in osteosarcoma.
Article in International orthopaedics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Current Treatment Options and Emerging Technologies for Pelvic Bone Tumors: From Limb Salvage to Precision Oncology.Current treatment options in oncology · 2026Review
- Precision oncology in the treatment of patients with bone sarcomas: an up-to-date narrative review.Exploration of targeted anti-tumor therapy · 2026Review
- A decision tree model suggests a strong interaction effect between tumor size and a close surgical margin on the prognosis of limb salvage surgery in high-grade osteosarcoma.Frontiers in surgery · 2026Article
- Research Progress on the Evaluation and Clinical Value of Negative Surgical Margins in Osteosarcoma.Orthopedic research and reviews · 2026Review
- Article
- Early diagnosis and treatment of low-grade myofibroblastic sarcoma in the left distal femur: a case report and literature review.BMC musculoskeletal disorders · 2025Review
- Sonographic characteristics of local soft tissue recurrence in primary bone tumor and diagnostic efficacy versus MRI.BMC cancer · 2025Article
- Prognostic Factors in High Grade Osteosarcoma Patients Who Received Neoadjuvant Therapy and Subsequently Underwent Surgery: Data from the Turkish Oncology Group.Journal of clinical medicine · 2025Article
- Osteosarcoma Management in the Precision Medicine Era: Bibliometric Analysis and Clinical Progress (2015-2024).The archives of bone and joint surgery · 2025Review
- Article
- Targeted anti-angiogenesis therapy for advanced osteosarcoma.Frontiers in oncology · 2024Review
- Robot-assisted implantation of additively manufactured patient-specific orthopaedic implants: evaluation in a sheep model.International journal of computer assisted radiology and surgery · 2023Article
- Does joint-sparing tumor resection jeopardize oncologic and functional outcomes in non-metastatic high-grade osteosarcoma around the knee?World journal of surgical oncology · 2023Article
- Limb-salvage surgery versus extremity amputation for early-stage bone cancer in the extremities: a population-based study.Frontiers in surgery · 2023Article
- Development and Validation of Nomogram-Based Prognosis Tools for Patients with Extremity Osteosarcoma: A SEER Population Study.Journal of oncology · 2022Article
- Limited utility of intraoperative frozen sections in primary malignant tumours involving long bones - A multicenter analysis of 475 cases.Annals of medicine and surgery (2012) · 2021Article
- Review
- Exosomes in osteosarcoma research and preclinical practice.American journal of translational research · 2021Review
- Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database.BMC cancer · 2020Article
- Guideline for Limb-Salvage Treatment of Osteosarcoma.Orthopaedic surgery · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWhether neoadjuvant chemotherapy safely allows close margins in osteosarcoma patients is still unknown. This study investigates the impact of close margins on local recurrence (LR) and overall survival (OS) for osteosarcoma patients treated with neoadjuvant chemotherapy.
methodsWe retrospectively reviewed 47 cases of conventional osteosarcoma who were treated at our institution. Patient and treatment factors such as age, gender, MSTS stage, tumour site, surgery type, pathological type, tumour size, surgical margin, tumour necrosis rate, chemotherapy regimens and cycles were recorded. A close margin was defined as tumour present less than 5 mm from the closest resection margin. The average followup was 87.6 months (range, 25-135 months).
resultsTwenty-five patients were alive, 22 patients had died, and eight had LR. Twenty-eight patients had wide margins, seven had positive margins and 12 had close margins. Positive margins had a greater risk of LR (57.1%) than wide margins and close margins. There was no difference in LR (8.3% vs 10.7%) between close margins and wide margins. Margin status was not correlated with OS.
conclusionCompared with wide margins, close margins did not lead to increased local recurrence in our study group. Whether close margins, as defined in our study, are just as acceptable as wide margins in terms of patient outcomes for osteosarcoma patients with neoadjuvant chemotherapy needs to be further confirmed in the future.
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