Evidence map›Paper›PMID 21403984›Full record

ReviewClinical orthopaedics and related research2011

The role of growth factors in cartilage repair.

Lisa A Fortier, Joseph U Barker, Eric J Strauss, Taralyn M McCarrel, Brian J Cole

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical orthopaedics and related research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07422662 (Single-blind Randomized Study on the Arthroscopic Treatment of Acetabular Labral Lesions), which is not on this map. Cited by 258 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
258citing papers in PubMed, 5 pooled it
25.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07422662 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Single-blind Randomized Study on the Arthroscopic Treatment of Acetabular Labral Lesions: Intrarticular Injection of Bone Marrow vs Hip Arthroscopy Alone

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2026 to 2032Enrolled80ConditionsFemoroAcetabular ImpingementArmsHip arthroscopy + BMAC injection, Hip arthroscopy
3 · Its place in the literature

Who cites it

258 citing papers in PubMed, 5 syntheses or guidelines pooled it, 629 citations in OpenAlex.

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198 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lisa A FortierDepartment of Clinical Sciences, VMC C3-181, Cornell University, Ithaca, NY 14853, USA. laf4@cornell.edu
Joseph U Barker
Eric J Strauss
Taralyn M McCarrel
Brian J Cole
Cornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFull-thickness chondral defects and early osteoarthritis continue to present major challenges for the patient and the orthopaedic surgeon as a result of the limited healing potential of articular cartilage. The use of bioactive growth factors is under consideration as a potential therapy to enhance healing of chondral injuries and modify the arthritic disease process. QUESTIONS/PURPOSES: We reviewed the role of growth factors in articular cartilage repair and identified specific growth factors and combinations of growth factors that have the capacity to improve cartilage regeneration. Additionally, we discuss the potential use of platelet-rich plasma, autologous-conditioned serum, and bone marrow concentrate preparations as methods of combined growth factor delivery.

methodsA PubMed search was performed using key words cartilage or chondrocyte alone and in combination with growth factor. The search was open for original manuscripts and review papers and open for all dates. From these searches we selected manuscripts investigating the effects of growth factors on extracellular matrix synthesis and excluded those investigating molecular mechanisms of action.

resultsBy modulating the local microenvironment, the anabolic and anticatabolic effects of a variety of growth factors have demonstrated potential in both in vitro and animal studies of cartilage injury and repair. Members of the transforming growth factor-β superfamily, fibroblast growth factor family, insulin-like growth factor-I, and platelet-derived growth factor have all been investigated as possible treatment augments in the management of chondral injuries and early arthritis.

conclusionsThe application of growth factors in the treatment of local cartilage defects as well as osteoarthritis appears promising; however, further research is needed at both the basic science and clinical levels before routine application.

Indexed as

AnimalsBone Morphogenetic ProteinsCartilage, ArticularCartilage DiseasesChondrogenesisDrug Therapy, CombinationFibroblast Growth FactorsHumansInsulin-Like Growth Factor IIntercellular Signaling Peptides and ProteinsPlatelet-Derived Growth FactorRegenerationTransforming Growth FactorsBone Morphogenetic ProteinsFibroblast Growth FactorsInsulin-Like Growth Factor IIntercellular Signaling Peptides and ProteinsPlatelet-Derived Growth FactorTransforming Growth Factors

Identifiers

PMID21403984
PMCPMC3171543
OpenAlexW2110032671

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.