ArticleParkinson's disease2011
Neuropathology and neurochemistry of nonmotor symptoms in Parkinson's disease.
Article in Parkinson's disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 71 citations in OpenAlex.
- Early-stage fasting leads to long-term growth inhibition and body composition changes in turbot (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Article
- Acupuncture for Parkinson's Disease: A Narrative Review of Clinical Efficacy and Mechanistic Insights.Neuropsychiatric disease and treatment · 2025Review
- Linalool, a Fragrance Compound in Plants, Protects Dopaminergic Neurons and Improves Motor Function and Skeletal Muscle Strength in Experimental Models of Parkinson's Disease.International journal of molecular sciences · 2024Article
- Article
- Acupuncture for Parkinson's Disease: Efficacy Evaluation and Mechanisms in the Dopaminergic Neural Circuit.Neural plasticity · 2021Review
- Detection of Articulatory Deficits in Parkinson's Disease: Can Systematic Manipulations of Phonetic Complexity Help?Journal of speech, language, and hearing research : JSLHR · 2020Article
- Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson's disease.Neuroscience and biobehavioral reviews · 2019Review
- Association Between Parkinson's Disease and Atrial Fibrillation: A Population-Based Study.Frontiers in neurology · 2019Article
- Peripheral Administration of Tetanus Toxin Hc Fragment Prevents MPPNeurotoxicity research · 2018Article
- Structure, Distribution, and Genetic Profile of α-Synuclein and Their Potential Clinical Application in Parkinson's Disease.Journal of movement disorders · 2017Article
- Qigong Exercise May Reduce Serum TNF-α Levels and Improve Sleep in People with Parkinson's Disease: A Pilot Study.Medicines (Basel, Switzerland) · 2017Article
- Default mode network differences between rigidity- and tremor-predominant Parkinson's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2016Article
- Effect of Acupuncture on the Motor and Nonmotor Symptoms in Parkinson's Disease--A Review of Clinical Studies.CNS neuroscience & therapeutics · 2016Review
- Current status of biomarker research in neurology.The EPMA journal · 2016Review
- Mechanism of Anti-α-Synuclein Immunotherapy.Journal of movement disorders · 2016Review
- Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease.Acta neuropathologica communications · 2015Article
- Alteration of Brain Functional Networks in Early-Stage Parkinson's Disease: A Resting-State fMRI Study.PloS one · 2015Article
- Relation between Olfactory Dysfunction and Episodic Verbal Memory in Early Parkinson's Disease.Noro psikiyatri arsivi · 2014Article
- Gender differences in Parkinson's disease: focus on plasma α-synuclein.Journal of neural transmission (Vienna, Austria : 1996) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson disease (PD) is no longer considered a complex motor disorder characterized by Parkinsonism but rather a systemic disease with variegated non-motor deficits and neurological symptoms, including impaired olfaction, autonomic failure, cognitive impairment, and psychiatric symptoms. Many of these alterations appear before or in parallel with motor deficits and then worsen with disease progression. Although there is a close relation between motor symptoms and the presence of Lewy bodies (LBs) and neurites filled with abnormal α-synuclein, other neurological alterations are independent of the amount of α-synuclein inclusions in neurons and neurites, thereby indicating that different mechanisms probably converge in the degenerative process. Involvement of the cerebral cortex that may lead to altered behaviour and cognition are related to several convergent factors such as (a) abnormal α-synuclein and other proteins at the synapses, rather than LBs and neurites, (b) impaired dopaminergic, noradrenergic, cholinergic and serotoninergic cortical innervation, and (c) altered neuronal function resulting from reduced energy production and increased energy demands. These alterations appear at early stages of the disease and may precede by years the appearance of cell loss and cortical atrophy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.