ArticleMediators of inflammation2010
Apocynin improves insulin resistance through suppressing inflammation in high-fat diet-induced obese mice.
Article in Mediators of inflammation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Peripheral metabolic dysfunction is associated with cognitive frailty in a mouse model of type 2 diabetes.Metabolic brain disease · 2026Article
- Apocynin Attenuates Diabetes-Induced Skeletal Muscle Dysfunction by Mitigating ROS Generation and Boosting Antioxidant Defenses in Fast-Twitch and Slow-Twitch Muscles.Life (Basel, Switzerland) · 2022Article
- Paracrine Role of the Endothelium in Metabolic Homeostasis in Health and Nutrient Excess.Frontiers in cardiovascular medicine · 2022Review
- Effects of Apocynin on Heart Muscle Oxidative Stress of Rats with Experimental Diabetes: Implications for Mitochondria.Antioxidants (Basel, Switzerland) · 2021Article
- AnJournal of biosciences · 2021Article
- NADPH Oxidase 2 Mediates Myocardial Oxygen Wasting in Obesity.Antioxidants (Basel, Switzerland) · 2020Article
- The role of glucose-6-phosphate dehydrogenase in adipose tissue inflammation in obesity.Adipocyte · 2017Article
- Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy.Oxidative medicine and cellular longevity · 2016Article
- Crucial roles of Nox2-derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle-aged mice.British journal of pharmacology · 2013Article
- NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents.Diabetologia · 2013Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effects of apocynin on high-fat diet- (HFD-) induced insulin resistance in C57BL/6 mice. After 12 weeks of HFD, the mice that exhibited insulin resistance then received 5 weeks of apocynin (2.4 g/L, in water). Following apocynin treatment, fasting glucose, insulin, and glucose tolerance test showed significant improvement in insulin sensitivity in HFD-fed mice. We demonstrated that serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and leptin were remarkably reduced with apocynin treatment. We also found that mRNA expression of TNF-α, IL-6, and monocyte chemoattractant protein-1 (MCP-1) in the liver and mRNA expression of TNF-α, IL-6, MCP-1, and leptin in adipose tissue were suppressed by apocynin. Furthermore, the activity of transcription factor NF-κB in the liver was significantly suppressed with apocynin treatment. These results suggest that apocynin may reduce inflammatory factors in the blood, liver, and adipose tissue, resulting in amelioration of insulin resistance in HFD-fed mice.
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