Evidence map›Paper›PMID 21403893›Full record

ArticleJournal of aging research2011

Physical activity and telomere biology: exploring the link with aging-related disease prevention.

Andrew T Ludlow, Stephen M Roth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of aging research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
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  8. Time Spent Jogging/Running and Biological Aging in 4458 U.S. Adults: An NHANES Investigation.International journal of environmental research and public health · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Association between socioeconomic markers and adult telomere length differs according to sex: Pro-Saúde study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020
    Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andrew T LudlowDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742-2611, USA.
Stephen M Roth
University of Maryland, College Park · US

Funding

PREDOCTORAL TRAINING IN EXERCISE PHYSIOLOGY AND AGINGT32AG000268 · NIA · UNIV OF MARYLAND, COLLEGE PARK · PI HAGBERG, JAMES M · 1999 to 2014
$2.5M
NIA NIH HHS T32 AG000268
6 · The paper itself

Abstract

Physical activity is associated with reduced risk of several age-related diseases as well as with increased longevity in both rodents and humans. Though these associations are well established, evidence of the molecular and cellular factors associated with reduced disease risk and increased longevity resulting from physical activity is sparse. A long-standing hypothesis of aging is the telomere hypothesis: as a cell divides, telomeres shorten resulting eventually in replicative senescence and an aged phenotype. Several reports have recently associated telomeres and telomere-related proteins to diseases associated with physical inactivity and aging including cardiovascular disease, insulin resistance, and hypertension. Interestingly several reports have also shown that longer telomeres are associated with higher physical activity levels, indicating a potential mechanistic link between physical activity, reduced age-related disease risk, and longevity. The primary purpose of this review is to discuss the potential importance of physical activity in telomere biology in the context of inactivity- and age-related diseases. A secondary purpose is to explore potential mechanisms and important avenues for future research in the field of telomeres and diseases associated with physical inactivity and aging.

Identifiers

PMID21403893
PMCPMC3043290
OpenAlexW2090904108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.