ArticleInternational journal of endocrinology2011
Improvement of hypertension after parathyroidectomy of patients suffering from primary hyperparathyroidism.
Article in International journal of endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Pooled it
- Serum uric acid is associated with left ventricular hypertrophy independent of serum parathyroid hormone in male cardiac patients.PloS one · 2013Trial
- Article
- Cardiovascular Morbidity in Patients Undergoing Successful Surgery for Primary Hyperparathyroidism.Clinical endocrinology · 2025Article
- High prevalence of hyperuricemia and its risk factors in a Chinese cohort of primary hyperparathyroidism patients.Endocrine · 2025Article
- The association between bone turnover biomarkers and the severity of white matter hyperintensities.Frontiers in neurology · 2025Article
- Sex differences in the relationship between parathyroid hormone and uric acid in osteoporotic fracture patients: insights from a retrospective cross-sectional study.Frontiers in endocrinology · 2025Article
- Is cardiovascular evaluation necessary for elderly patients with primary hyperparathyroidism?Gland surgery · 2024Article
- Parathyroid diseases and metabolic syndrome.Journal of endocrinological investigation · 2023Review
- Improvement of hypertension control and left-ventricular function after cure of primary hyperparathyroidism.Frontiers in endocrinology · 2023Article
- Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism.Journal of clinical medicine · 2022Article
- Impact of curative parathyroidectomy on left ventricular functions assessed with 2D ECHO and MUGA study.Turkish journal of surgery · 2021Article
- Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence.International journal of molecular sciences · 2021Review
- Vitamin D and uric acid: Is parathyroid hormone the missing link?Journal of clinical & translational endocrinology · 2021Article
- Unusual cause of resistant hypertension in a 33-year-old woman with a palpable parathyroid nodule.BMJ case reports · 2021Article
- High blood pressure as the first manifestation and multiple organ dysfunction in primary hyperparathyroidism: a case report.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Primary hyperparathyroidism and hypertension.Gland surgery · 2020Review
- The Interplay Between the Renin-Angiotensin-Aldosterone System and Parathyroid Hormone.Frontiers in endocrinology · 2020Review
- Plasma parathyroid hormone and cardiovascular disease in treatment-naive patients with primary hyperparathyroidism: The EPATH trial.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- A case of acute confusion: Cushing's syndrome presenting with primary hyperparathyroidism.BMJ case reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Primary hyperparathyroidism (PHPT) is one of the most common endocrine conditions and is accompanied by hypertension and increased cardiovascular mortality. The purpose of this study was to evaluate the effect of parathyroidectomy on systolic and diastolic blood pressure (BP) in hypertensive patients with PHPT and whether hypertension occurs more frequently in PHPT than in control group. Methods. A total of 1020 patients with proved PHPT who underwent surgery were compared with with 1020 age, sex, BMI, and smoking status matched controls. We evaluated changes in serum calcium, parathyroid hormone (PTH), uric acid, and BP before and 6 months after surgery. Results. Parathyroidectomy corrected PHPT and resulted in a substantial fall in both mean systolic (150 ± 3.8 to 138 ± 3.6 mmHg) and mean diastolic pressures (97 ± 3 to 88 ± 2.8 mmHg) of the hypertensive subjects; P < .01. In these patients, PTH, calcium, and uric acid normalized. 726 patients from 1020 with PHPT (69.8%) were found to be hypertensive whilst only 489 (47.8%) from 1020 of our control group. Conclusion. Parathyroidectomy in hypertensive patients reduces systolic and diastolic BP. PHPT is accompanied by a variety of metabolic complications, which are a risk factor for hypertension, and parathyroidectomy can improve these metabolic complications.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.