ArticleCardiology research and practice2011
Increased left ventricular stiffness impairs exercise capacity in patients with heart failure symptoms despite normal left ventricular ejection fraction.
Article in Cardiology research and practice, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Evaluating Diastolic Dysfunction in Children with Congenital Heart Disease: The Role of Stiffness ConstantJournal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Microtubule destabilization with colchicine increases the work output of myocardial slices.Journal of molecular and cellular cardiology plus · 2024Article
- Understanding heterogeneous mechanisms of heart failure with preserved ejection fraction through cardiorenal mathematical modeling.PLoS computational biology · 2023Article
- A Novel Strategy to Fit and Validate Physiological Models: A Case Study of a Cardiorespiratory Model for Simulation of Incremental Aerobic Exercise.Diagnostics (Basel, Switzerland) · 2023Article
- Echocardiographic Detection of Increased Ventricular Diastolic Stiffness in Pediatric Heart Transplant Recipients: A Pilot Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2018Article
- Longer Ischemic Time is Associated with Increased Ventricular Stiffness as Measured by Pressure-Volume Loop Analysis in Pediatric Heart Transplant Recipients.Pediatric cardiology · 2018Article
- Heart failure with preserved ejection fraction: current management and future strategies : Expert opinion on the behalf of the Nucleus of the "Heart Failure Working Group" of the German Society of Cardiology (DKG).Clinical research in cardiology : official journal of the German Cardiac Society · 2018Review
- Cardiac MR elastography of the mouse: Initial results.Magnetic resonance in medicine · 2016Article
- Diastolic dysfunction measured by cardiac magnetic resonance imaging in women with signs and symptoms of ischemia but no obstructive coronary artery disease.International journal of cardiology · 2016Article
- Role of Diastolic Function in Preserved Exercise Capacity in Patients with Reduced Ejection Fractions.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2015Article
- Heterogeneous responses of systolic and diastolic left ventricular function to exercise in patients with heart failure and preserved ejection fraction.ESC heart failure · 2015Article
- Grading diastolic function by echocardiography: hemodynamic validation of existing guidelines.Cardiovascular ultrasound · 2015Article
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Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims. Several mechanisms can be involved in the development of exercise intolerance in patients with heart failure despite normal left ventricular ejection fraction (HFNEF) and may include impairment of left ventricular (LV) stiffness. We therefore investigated the influence of LV stiffness, determined by pressure-volume loop analysis obtained by conductance catheterization, on exercise capacity in HFNEF. Methods and Results. 27 HFNEF patients who showed LV diastolic dysfunction in pressure-volume (PV) loop analysis performed symptom-limited cardiopulmonary exercise testing (CPET) and were compared with 12 patients who did not show diastolic dysfunction in PV loop analysis. HFNEF patients revealed a lower peak performance (P = .046), breathing reserve (P = .006), and ventilation equivalent for carbon dioxide production at rest (P = .002). LV stiffness correlated with peak oxygen uptake (r = -0.636, P < .001), peak oxygen uptake at ventilatory threshold (r = -0.500, P = .009), and ventilation equivalent for carbon dioxide production at ventilatory threshold (r = 0.529, P = .005). Conclusions. CPET parameters such as peak oxygen uptake, peak oxygen uptake at ventilatory threshold, and ventilation equivalent for carbon dioxide production at ventilatory threshold correlate with LV stiffness. Increased LV stiffness impairs exercise capacity in HFNEF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.