ReviewJournal of biomedicine & biotechnology2011
Modulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock.
Review in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- The protective effect of irisin against hemorrhagic injury is mediated by PI3K and p38 pathways in hemorrhage/resuscitation.The Journal of pharmacology and experimental therapeutics · 2025Article
- Multimodal nanoparticle-containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation.Bioengineering & translational medicine · 2024Article
- Vagus nerve stimulation attenuates septic shock-induced cardiac injury in rats.Physiological research · 2023Article
- Modified Suberoylanilide Hydroxamic Acid Reduced Drug-Associated Immune Cell Death and Organ Damage under Lipopolysaccharide Inflammatory Challenge.ACS pharmacology & translational science · 2022Article
- Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype.Journal of inflammation research · 2022Article
- HDAC Inhibition as Potential Therapeutic Strategy to Restore the Deregulated Immune Response in Severe COVID-19.Frontiers in immunology · 2022Article
- Ring finger protein 219 regulates inflammatory responses by stabilizing sirtuin 1.British journal of pharmacology · 2020Article
- Impact of cytomegalovirus load on host response to sepsis.Medical microbiology and immunology · 2019Review
- ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1.International journal of molecular sciences · 2019Article
- Annexin A1 Bioactive Peptide Promotes Resolution of Neuroinflammation in a Rat Model of Exsanguinating Cardiac Arrest Treated by Emergency Preservation and Resuscitation.Frontiers in neuroscience · 2019Article
- Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine.Journal of visualized experiments : JoVE · 2018Article
- Article
- Timing of valproic acid in acute lung injury: prevention is the best therapy?The Journal of surgical research · 2017Article
- Mitochondrial dysfunction in rat splenocytes following hemorrhagic shock.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock.Inflammation · 2017Article
- Inhibition of histone deacetylase 6 restores intestinal tight junction in hemorrhagic shock.The journal of trauma and acute care surgery · 2016Article
- Trichostatin A Protects Liver against Septic Injury through Inhibiting Toll-Like Receptor Signaling.Biomolecules & therapeutics · 2016Article
- Inhibition of peptidylarginine deiminase attenuates inflammation and improves survival in a rat model of hemorrhagic shock.The Journal of surgical research · 2016Article
- Inhibition of histone deacetylase 6 restores innate immune cells in the bone marrow in a lethal septic model.The journal of trauma and acute care surgery · 2016Article
- Selective inhibition of histone deacetylase 6 promotes survival in a rat model of hemorrhagic shock.The journal of trauma and acute care surgery · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histone and nonhistone proteins and in regulating fundamental cellular activities. In this paper we review and discuss intriguing recent developments in the use of histone deacetylase inhibitors (HDACIs) to combat some critical conditions in an animal model of hemorrhagic and septic shock. HDACIs have neuroprotective, cardioprotective, renal-protective, and anti-inflammatory properties; survival improvements have been significantly shown in these models. We discuss the targets and mechanisms underlying these effects of HDACIs and comment on the potential new clinical applications for these agents in the future. This paper highlights the emerging roles of HDACIs as acetylation modulators in models of hemorrhagic and septic shock and explains some contradictions encountered in previous studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.