ArticleMolecular vision2011
Decreased 1,25-Dihydroxyvitamin D3 level is involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Vitamin D and Ocular Diseases: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Advances in the Study of the Pathogenesis of Vogt-Koyanagi- Harada Syndrome.Current molecular medicine · 2025Review
- Vitamin D status in active and inactive noninfectious uveitis - data from a reference university hospital in Rio de Janeiro, Brazil.Arquivos brasileiros de oftalmologia · 2024Article
- Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases.Nutrients · 2022Review
- Impact of dietary vitamin D on immunoregulation and disease pathology in lupus-prone NZB/W F1 mice.Frontiers in immunology · 2022Article
- Serum 25-hydroxyvitamin D concentration in Japanese Akita dogs: A survey.Veterinary and animal science · 2020Article
- Genetic variations in autoimmune genes and VKH disease.International ophthalmology · 2020Review
- Vitamin D deficiency is associated with higher disease activity and the risk for uveitis in juvenile idiopathic arthritis - data from a German inception cohort.Arthritis research & therapy · 2018Observational
- Association of Hypovitaminosis D With Increased Risk of Uveitis in a Large Health Care Claims Database.JAMA ophthalmology · 2018Article
- Epidemiology of uveitis in a US population-based study.Journal of ophthalmic inflammation and infection · 2018Article
- Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease.Molecular vision · 2017Article
- Sequence analysis of four vitamin D family genes (VDR, CYP24A1, CYP27B1 and CYP2R1) in Vogt-Koyanagi-Harada (VKH) patients: identification of a potentially pathogenic variant in CYP2R1.BMC ophthalmology · 2016Article
- SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.Free radical biology & medicine · 2014Article
- Vitamin D receptor as a therapeutic target for benign prostatic hyperplasia.Indian journal of urology : IJU : journal of the Urological Society of India · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose1,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] has recently been found to be involved in the development of autoimmune diseases. This study was to investigate the expression and potential role of 1,25(OH)(2)D(3) in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease.
methodsBlood samples were obtained from VKH patients and healthy individuals. Serum 1,25(OH)(2)D(3) levels were measured using ELISA. Peripheral blood mononuclear cells (PBMCs) or cluster of differentiation (CD) 4(+) T cells were cultured with or without 1,25(OH)(2)D(3) in the presence of anti-CD3 and anti-CD28 for the measurement of cell proliferation and cytokines. The cell proliferation was detected using the Cell Counting Kit. The levels of interleukin (IL)-17 and interferon (IFN)-γ levels in the supernatants of PBMCs or CD4(+) T cells were detected by ELISA.
results1,25(OH)(2)D(3) was significantly decreased in the serum of active VKH patients as compared with inactive VKH patients and controls. It significantly inhibited PBMCs proliferation and CD4(+) T cell proliferation. It was also able to significantly inhibit the production of IL-17 and IFN-γ by both PBMCs and CD4(+) T cells from VKH patients and controls.
conclusionsThese findings suggest that decreased expression of 1,25(OH)(2)D(3) may be involved in the development of VKH disease. 1,25(OH)(2)D(3) may be potentially used in the treatment of this disease.
Indexed as
Identifiers
21403851PMC3056125W1608671678What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.