ArticleNeoplasia (New York, N.Y.)2011
Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.
Article in Neoplasia (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 397 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
397 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glycolytic pathway candidate markers in the prognosis of oral squamous cell carcinoma: a systematic review with meta-analysis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Pooled it
- A Static Phantom for Harmonization of Hyperpolarized [1-Magnetic resonance in medicine · 2026Article
- Nonresonant SABRE provides an additional versatile hyperpolarization approach in magnetic resonance.Science advances · 2026Article
- High-resolution microtesla in-situJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026Article
- Complementary hyperpolarizedNpj imaging · 2026Article
- On the effects of hyperpolarized water-based dissolution on the solute and solventPhysical chemistry chemical physics : PCCP · 2026Article
- The role of tumor metabolic reprogramming in acquired anti-PD-1/PD-L1 resistance.Translational lung cancer research · 2026Review
- 14.1 T Liquid-StateJournal of the American Chemical Society · 2026Article
- From Unlocking Pyruvate Hyperpolarization by Signal Amplification by Reversible Exchange (SABRE) to Clinical Prospects.ACS omega · 2026Review
- Long-lived coherences for the observation of oxidation kinetics on different timescales by NMR.Communications chemistry · 2026Article
- Multidimensional pH-Temperature Mapping of SABRE-SHEATHThe journal of physical chemistry. B · 2025Article
- Hyperpolarized Carbon-13 Metabolic Imaging Differentiates Distinctive Molecular Phenotypes in Diffuse Midline Gliomas.Molecules (Basel, Switzerland) · 2025Article
- Probing Intracellular Yeast Metabolism With Deuterium Magnetic Resonance Spectroscopy.NMR in biomedicine · 2025Article
- Distance-Dependence of Photo-CIDNP in Biomimetic Tryptophan-Flavin Diads.Angewandte Chemie (International ed. in English) · 2025Article
- EfficientJournal of magnetic resonance open · 2025Article
- Article
- Toward Generalized Solution-StateThe journal of physical chemistry letters · 2025Article
- Hyperpolarized [1-Scientific reports · 2025Article
- Parahydrogen-Hyperpolarized Propane-The journal of physical chemistry. A · 2025Article
- RASER for Increased Spectral Resolution in Carbon-13 NMR.Analytical chemistry · 2025Article
337 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the goal of improved diagnosis and perhaps therapy. Because of the complexity of biochemical pathways, tracer methods are required for detecting specific enzyme-catalyzed reactions. Stable isotopes such as (13)C or (15)N with detection by nuclear magnetic resonance provide the necessary information about tissue biochemistry, but the crucial metabolites are present in low concentration and therefore are beyond the detection threshold of traditional magnetic resonance methods. A solution is to improve sensitivity by a factor of 10,000 or more by temporarily redistributing the populations of nuclear spins in a magnetic field, a process termed hyperpolarization. Although this effect is short-lived, hyperpolarized molecules can be generated in an aqueous solution and infused in vivo where metabolism generates products that can be imaged. This discovery lifts the primary constraint on magnetic resonance imaging for monitoring metabolism-poor sensitivity-while preserving the advantage of biochemical information. The purpose of this report was to briefly summarize the known abnormalities in cancer metabolism, the value and limitations of current imaging methods for metabolism, and the principles of hyperpolarization. Recent preclinical applications are described. Hyperpolarization technology is still in its infancy, and current polarizer equipment and methods are suboptimal. Nevertheless, there are no fundamental barriers to rapid translation of this exciting technology to clinical research and perhaps clinical care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.