ArticleInternational journal of general medicine2011
Role of glutathione in immunity and inflammation in the lung.
Article in International journal of general medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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Who cites it
101 citing papers in PubMed, 242 citations in OpenAlex.
- Influence of Synbiotics on Selected Oxidative Stress Parameters.Oxidative medicine and cellular longevity · 2017Trial
- Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways.Respiratory research · 2015Trial
- Effects of synbiotic supplementation on oxidative stress biomarkers in adults: an updated GRADE-assessed systematic review and meta-analysis of randomized controlled trials.Genes & nutrition · 2026Review
- Redox status of apolipoprotein E in cerebrospinal fluid: a mechanistically informative biomarker for central nervous system disorders.Bioscience reports · 2026Article
- A comparative analysis of oral microbial communities in hypertensive patients with and without chronic periodontitis.BMC oral health · 2026Article
- An immune-mediated effect of the antibiotic cefiderocol on LPS-induced acute lung injury.Antimicrobial agents and chemotherapy · 2026Article
- Inflammatory and Redox Responses During Medical Treatment of Open-Cervix Pyometra in Female Dogs: A Prospective Study.Animals : an open access journal from MDPI · 2025Article
- Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Current Insights into Glutathione Depletion in Adult Septic Patients.Antioxidants (Basel, Switzerland) · 2025Review
- A lipidomic approach towards identifying the effects of fragrance hydroperoxides on keratinocytes.Contact dermatitis · 2025Article
- Metabolic Reprogramming in Response to Freund's Adjuvants: Insights from Serum Metabolomics.Microorganisms · 2025Article
- Molecular Approach of Oxidative Stress and Bronchopulmonary Dysplasia: Relationship of GSTM1 and GSTT1 Genes.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Review
- Glutathione and neurodegenerative diseases: immunopharmacological implications.Frontiers in pharmacology · 2025Review
- Transcriptomic and Metabolomics Joint Analyses Reveal the Influence of Gene and Metabolite Expression in Blood on the Lactation Performance of Dual-Purpose Cattle (International journal of molecular sciences · 2024Article
- The Effects of Different Respiratory Viruses on the Oxidative Stress Marker Levels in an In Vitro Model: A Pilot Study.International journal of molecular sciences · 2024Article
- Novel therapeutic targets for major depressive disorder related to oxidative stress identified by integrative multi-omics and multi-trait study.Translational psychiatry · 2024Article
- Evaluation of the therapeutic potential of novel nanoparticle formulations of glutathione and virgin coconut oil in an experimental model of carbon tetrachloride-induced liver failure.BMC pharmacology & toxicology · 2024Article
- Different Combinations of Nitrogen and Carbon Sources Influence the Growth and Postbiotic Metabolite Characteristics ofFoods (Basel, Switzerland) · 2024Article
- Therapeutic Benefits of Tuna Oil by In Vitro and In Vivo Studies Using a Rat Model of Acetic Acid-Induced Ulcerative Colitis.Applied biochemistry and biotechnology · 2024Article
- Significance and Applications of the Thermo-Acidophilic MicroalgaPlants (Basel, Switzerland) · 2024Review
41 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
Reactive oxygen species and thiol antioxidants, including glutathione (GSH), regulate innate immunity at various levels. This review outlines the redox-sensitive steps of the cellular mechanisms implicated in inflammation and host defense against infection, and describes how GSH is not only important as an antioxidant but also as a signaling molecule. There is an extensive literature of the role of GSH in immunity. Most reviews are biased by an oversimplified picture where "bad" free radicals cause all sorts of diseases and "good" antioxidants protect from them and prevent oxidative stress. While this may be the case in certain fields (eg, toxicology), the role of thiols (the topic of this review) in immunity certainly requires wearing scientist's goggles and being prepared to accept a more complex picture. This review aims at describing the role of GSH in the lung in the context of immunity and inflammation. The first part summarizes the history and basic concepts of this picture. The second part focuses on GSH metabolism/levels in pathology, the third on the role of GSH in innate immunity and inflammation, and the fourth gives 4 examples describing the importance of GSH in the response to infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.