ArticleAnnals of family medicine
Patients with type 2 diabetes at risk for major depressive disorder over time.
Article in Annals of family medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Unveiling the relationship of the comorbidity between depression and type 2 diabetes mellitus: a macro analysis and micro interpretation.Frontiers in medicine · 2026Pooled it
- The bidirectional longitudinal association between depressive symptoms and HbADiabetic medicine : a journal of the British Diabetic Association · 2022Pooled it
- Perceptions of Provider Communication Among Vulnerable Patients With Diabetes: Influences of Medical Mistrust and Health Literacy.Journal of health communication · 2016Trial
- Biological mechanism and functional verification of key genes related to major depressive disorder and type 2 diabetes mellitus.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Factors associated with the onset of major depressive disorder in adults with type 2 diabetes living in 12 different countries: results from the INTERPRET-DD prospective study.Epidemiology and psychiatric sciences · 2020Article
- Physician-patient interactions in African American patients with systemic lupus erythematosus: Demographic characteristics and relationship with disease activity and depression.Seminars in arthritis and rheumatism · 2019Article
- Psychosocial interventions for reducing diabetes distress in vulnerable people with type 2 diabetes mellitus: a systematic review and meta-analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
- Prevalence of depression in patients with type 2 diabetes mellitus in Spain (the DIADEMA Study) : results from the MADIABETES cohort.BMJ open · 2018Article
- The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features.Journal of Alzheimer's disease : JAD · 2018Review
- Article
- Comorbidity of depression and diabetes: an application of biopsychosocial model.International journal of mental health systems · 2016Article
- Depression in romanian patients with type 2 diabetes: prevalence and risk factors.Clujul medical (1957) · 2016Article
- The association between diabetes and depression.Saudi medical journal · 2015Article
- Review
- Stress, depression and medication nonadherence in diabetes: test of the exacerbating and buffering effects of family support.Journal of behavioral medicine · 2015Article
- Prevalence of Depression among Type 2 Diabetic Outpatients in Black Lion General Specialized Hospital, Addis Ababa, Ethiopia.Depression research and treatment · 2015Article
- Prevalence and influencing factors of co-morbid depression in patients with type 2 diabetes mellitus: a General Hospital based study.Diabetology & metabolic syndrome · 2015Article
- Clinical impact of the temporal relationship between depression and type 2 diabetes: the Fremantle diabetes study phase II.PloS one · 2013Article
- Health and psychosocial outcomes in U.S. adult patients with diabetes from diverse ethnicities.Current diabetes reports · 2012Review
- Effect of comorbid depression on outcomes in diabetes and its relationship to quality of care and patient adherence: a statewide primary care ambulatory research and resources consortium study.The primary care companion for CNS disorders · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe wanted to identify risk factors associated with the development of major depressive disorder (MDD) among patients with type 2 diabetes over time.
methodsIn a noninterventional study, 338 adult patients with type 2 diabetes and no MDD diagnosis at baseline were assessed 3 times during 18 months (9-month intervals) to ascertain predictors of MDD. We tested a model incorporating personal, behavioral, biologic, and psychosocial variables to identify predictors of MDD. Exploratory analyses tested whether current negative affect mediated the relationship between predictors and subsequent MDD. We also conducted a stratified analysis of moderate vs high negative affect to explore whether level of baseline negative affect mediated the relationship between specific predictors and MDD.
resultsPrior MDD and negative affect predicted future development of MDD. In subpopulations stratified by moderate negative affect, negative life events, an elevated body mass index (BMI), prior MDD, and poor control of glycated hemoglobin (hemoglobin A(1c)) each predicted MDD. In subpopulations stratified by elevated negative affect, negative life events and poor control of hemoglobin A(1c) predicted MDD. Current negative affect partially mediated the relationship between prior MDD and subsequent MDD, as well as the relationship between negative life events and subsequent MDD.
conclusionsAlthough negative affect at baseline was the primary predictor of subsequent MDD, when stratified by negative affect, negative life events, BMI, and poor control of hemoglobin A(1c) also predicted MDD. Thus, life stresses and patients' disease-related concerns are important when understanding what predicts subsequent MDD. Addressing depressive symptoms and broader life context issues expands the scope of a potential intervention to reduce the risk of developing MDD in persons with type 2 diabetes.
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