ArticleProceedings of the National Academy of Sciences of the United States of America2011
Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
44 citing papers in PubMed.
- Single-cell gene expression and TCR profiling reveal age-related differences in recent thymic emigrants.iScience · 2026Article
- Functionally heterogeneous intratumoral CD4Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neonatal liver niches program T cell tolerance.bioRxiv : the preprint server for biology · 2026Article
- Recent thymic emigrants preferentially undergo memory inflation after persistent infection.PLoS pathogens · 2025Article
- Case Report: A patient with a novel heterozygous IRF8 variant with repeated infection and immune-mediated organ disease, but without disseminated mycobacterial disease despite BCG immunization.Frontiers in immunology · 2025Article
- Internal regulation between constitutively expressed T cell co-inhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants.Open biology · 2024Article
- Comprehensive Flow Cytometric, Immunohistologic, and Molecular Assessment of Thymus Function in Rhesus Macaques.ImmunoHorizons · 2024Article
- Exercise to Prevent Accelerated Vascular Aging in People Living With HIV.Circulation research · 2024Review
- Sex-specific differences in ICOSClinical and experimental medicine · 2024Article
- PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age.JCI insight · 2024Article
- The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy and oncolytic virotherapy.Frontiers in immunology · 2024Review
- Modeling T Cell Fate.Annual review of immunology · 2023Review
- Article
- Evaluation of Thymic Output and Regulatory T Cells in Kidney Transplant Recipients with Chronic Antibody-Mediated Rejection.BioMed research international · 2021Article
- CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Associations between recent thymic emigrants and CD4+ T-cell recovery after short-term antiretroviral therapy initiation.AIDS (London, England) · 2020Article
- Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells.The Journal of experimental medicine · 2020Article
- Cosmc is required for T cell persistence in the periphery.Glycobiology · 2019Article
- Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates.Aging cell · 2019Article
- The full spectrum of human naive T cells.Nature reviews. Immunology · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent thymic emigrants (RTEs) are the youngest subset of peripheral T cells, and they differ functionally and phenotypically from the rest of the naïve T-cell pool. RTEs are present in the peripheral T-cell pool throughout life but are the most common subset of T cells in neonates and adults recovering from lymphoablation. Using a murine model to study the homeostasis of RTEs, we show that under lymphoreplete conditions, RTEs are at a competitive disadvantage to already established mature naïve (MN) T cells. This disadvantage may be caused by a defect in survival, because RTEs may transduce homeostatic signals inefficiently, and their ability to survive is enhanced with increased expression of IL-7 receptor or B-cell lymphoma 2 (Bcl-2). Conversely, under lymphopenic conditions, enhanced proliferation by RTEs allows them to out-compete their MN T-cell counterparts. These results suggest that in times of need, such as in neonates or lymphopenic adults, RTEs perform well to fill the gaps in the peripheral T-cell pool, but when the periphery already is full, many RTEs are not incorporated into the pool of recirculating lymphocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.