ArticleAntimicrobial agents and chemotherapy2011
A new small molecule specifically inhibits the cariogenic bacterium Streptococcus mutans in multispecies biofilms.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Benefits and Implications of Resveratrol Supplementation on Microbiota Modulations: A Systematic Review of the Literature.International journal of molecular sciences · 2022Pooled it
- TargetingACS medicinal chemistry letters · 2026Article
- Coumarin-Mediated Inhibition of Diadenylate Cyclase Correlates with Impaired Biofilm Formation inACS infectious diseases · 2026Article
- Probiotics, Prebiotics, Synbiotics, Postbiotics, and Bioactive Agents in Modulating Harmful Oral Biofilms.Probiotics and antimicrobial proteins · 2026Review
- Chemical inhibition of MrkH-dependent activation of type 3 fimbriae synthesis and biofilm formation by Klebsiella pneumoniae.NPJ biofilms and microbiomes · 2025Article
- Computational-aided drug design strategies for drug discovery and development against oral diseases.Frontiers in pharmacology · 2025Review
- Polymer vesicles for the delivery of inhibitors of cariogenic biofilm.Dental materials : official publication of the Academy of Dental Materials · 2024Article
- Association between untreated caries and cariogenic bacteria in adolescents in Taiwan.Journal of dental sciences · 2024Article
- The Mechanisms and Application Value of Postbiotics in Caries Prevention and Management.Oral health & preventive dentistry · 2024Review
- Intraspecies interactions ofmSphere · 2024Article
- Tetracyclic homoisoflavanoid (+)-brazilin: a natural product inhibits c-di-AMP-producing enzyme andMicrobiology spectrum · 2024Article
- Article
- Hydrogel-Encapsulated Biofilm Inhibitors Abrogate the Cariogenic Activity ofJournal of medicinal chemistry · 2023Article
- Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment.Microorganisms · 2023Review
- [Materials for Selective Inhibition ofSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Discovery of Novel Iminosugar Compounds Produced byMicrobiology spectrum · 2022Article
- Evolution of two-component quorum sensing systems.Access microbiology · 2022Article
- Novel antimicrobial agents targeting theFrontiers in cellular and infection microbiology · 2022Review
- Strategies for dispersion of cariogenic biofilms: applications and mechanisms.Frontiers in microbiology · 2022Review
- The Application of Small Molecules to the Control of Typical Species Associated With Oral Infectious Diseases.Frontiers in cellular and infection microbiology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Streptococcus mutans is a major cariogenic bacterium. It has adapted to the biofilm lifestyle, which is essential for pathogenesis of dental caries. We aimed to identify small molecules that can inhibit cariogenic S. mutans and to discover lead structures that could give rise to therapeutics for dental caries. In this study, we screened a focused small-molecule library of 506 compounds. Eight small molecules which inhibited S. mutans at a concentration of 4 μM or less but did not affect cell growth or biofilm formation of commensal bacteria, represented by Streptococcus sanguinis and Streptococcus gordonii, in monospecies biofilms were identified. The active compounds share similar structural properties, which are characterized by a 2-aminoimidazole (2-AI) or 2-aminobenzimidazole (2-ABI) subunit. In multispecies biofilm models, the most active compound also inhibited cell survival and biofilm formation of S. mutans but did not affect commensal streptococci. This inhibitor downregulated the expression of six biofilm-associated genes, ftf, pac, relA, comDE, gbpB, and gtfB, in planktonic S. mutans cells, while it downregulated the expression of only ftf, pac, and relA in the biofilm cells of S. mutans. The most potent compound also inhibited production of two key adhesins of S. mutans, antigen I/II and glucosyltransferase (GTF). However, the compound did not alter the expression of the corresponding genes in both S. sanguinis and S. gordonii, indicating that it possesses a selective inhibitory activity against S. mutans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.