Evidence map›Paper›PMID 21402857›Full record

ArticleAntimicrobial agents and chemotherapy2011

Pharmacokinetics of anidulafungin in pleural fluid during the treatment of a patient with Candida empyema.

Brad Moriyama, Marisa Ditullio, Eleanor Wilson, Stacey A Henning, Scott R Penzak, Robert L Danner, Gennethel Pennick, Michael G Rinaldi, Adrian M Zelazny, Juan Gea-Banacloche and 2 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Candida.JHLT open · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Journal of fungi (Basel, Switzerland) · 2022
    Article
  8. A Case Report ofFrontiers in public health · 2022
    Article
  9. Open forum infectious diseases · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Tissue penetration of antifungal agents.Clinical microbiology reviews · 2014
    Review
  14. Article
  15. A 19-year-old woman with pleuritic chest pain.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Brad MoriyamaNIH Clinical Center, Pharmacy Department, National Heart Lung and Blood Instititute, Bethesda, MD, USA.
Marisa Ditullio
Eleanor Wilson
Stacey A Henning
Scott R Penzak
Robert L Danner
Gennethel Pennick
Michael G Rinaldi
Adrian M Zelazny
Juan Gea-Banacloche
A John Barrett
Thomas J Walsh
National Institutes of Health Clinical Center · USNational Heart Lung and Blood Institute · USNational Institutes of Health · USThe University of Texas Health Science Center at San Antonio · USCornell University · USNational Cancer Institute · USNational Institute of Allergy and Infectious Diseases · US

Funding

improving outcomes after stem cell transplantationZIAHL006105 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BARRETT, AUSTIN JOHN · 2011 to 2017
$11.5M
Immunobiology and immunotherapy of leukemiaZIAHL006106 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BARRETT, AUSTIN JOHN · 2011 to 2017
$8.6M
Characterization and improvement of graft versus leukemia effectsZIAHL006107 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BARRETT, AUSTIN JOHN · 2011 to 2017
$8.6M
Intramural NIH HHS
6 · The paper itself

Abstract

Candida empyema is a serious complication of disseminated candidiasis. However, little is known about the intrapleural pharmacokinetics of echinocandins. We report the penetration of anidulafungin into the pleural fluid of a patient with Candida tropicalis empyema. The anidulafungin ratio for the area under the concentration-time curve from 0 h to the last measurement between pleural fluid and serum values was only 0.125 (12.5%), with pleural fluid concentrations ranging between 0.67 and 0.88 μg/ml.

Indexed as

AdultAnidulafunginAntifungal AgentsCandidaEchinocandinsEmpyemaEmpyema, PleuralHumansMaleAnidulafunginAntifungal AgentsEchinocandins

Identifiers

PMID21402857
PMCPMC3088219
OpenAlexW2127116329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.