ArticleMolecular and cellular biology2011
Essential and redundant functions of caudal family proteins in activating adult intestinal genes.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 104 citations in OpenAlex.
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- Tissue-location-specific transcription programs drive tumor dependencies in colon cancer.Nature communications · 2024Article
- Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.Nature cell biology · 2024Article
- The Assessment ofActa medica Lituanic · 2024Article
- Hungatella hathewayi impairs the sensitivity of colorectal cancer cells to 5-FU through decreasing CDX2 expression.Human cell · 2023Article
- Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action.Chinese medicine · 2023Review
- Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut.Development (Cambridge, England) · 2022Article
- SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling.Cell stem cell · 2022Article
- Pathological Features and Prognostication in Colorectal Cancer.Current oncology (Toronto, Ont.) · 2021Review
- P63 Deficiency and CDX2 Overexpression Lead to Barrett's-Like Metaplasia in Mouse Esophageal Epithelium.Digestive diseases and sciences · 2021Article
- The Diagnostic Value of Cadherin 17 and CDX2 Expression as Immunohistochemical Markers in Colorectal Adenocarcinoma.Journal of gastrointestinal cancer · 2021Article
- Cdx2 regulates immune cell infiltration in the intestine.Scientific reports · 2021Article
- CDX2 regulates interleukin-33 gene expression in intestinal epithelial cells (LS174T).FEBS open bio · 2021Article
- 3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation.Journal of visualized experiments : JoVE · 2021Article
- Article
- Identification of Transcription Factors Regulating SARS-CoV-2 Entry Genes in the Intestine.Cellular and molecular gastroenterology and hepatology · 2021Article
- Chromatin Dynamics in Intestinal Epithelial Homeostasis: A Paradigm of Cell Fate Determination versus Cell Plasticity.Stem cell reviews and reports · 2020Review
- Caudal type homeoboxes as a driving force inGut microbes · 2020Article
- BRAFOncogene · 2020Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Transcription factors that potently induce cell fate often remain expressed in the induced organ throughout life, but their requirements in adults are uncertain and varied. Mechanistically, it is unclear if they activate only tissue-specific genes or also directly repress heterologous genes. We conditionally inactivated mouse Cdx2, a dominant regulator of intestinal development, and mapped its genome occupancy in adult intestinal villi. Although homeotic transformation, observed in Cdx2-null embryos, was absent in mutant adults, gene expression and cell morphology were vitally compromised. Lethality was significantly accelerated in mice lacking both Cdx2 and its homolog Cdx1, with particular exaggeration of defects in villus enterocyte differentiation. Importantly, Cdx2 occupancy correlated with hundreds of transcripts that fell but not with equal numbers that rose with Cdx loss, indicating a predominantly activating role at intestinal cis-regulatory regions. Integrated consideration of a transcription factor's mutant phenotype and cistrome hence reveals the continued and distinct requirement in adults of a critical developmental regulator that activates tissue-specific genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.