ArticleInfection and immunity2011
Participation of CD11c(+) leukocytes in methicillin-resistant Staphylococcus aureus clearance from the lung.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 50 citations in OpenAlex.
- Integrative multi-omics reveals CUL4B as a modulator of macrophage pyroptosis and innate defense againstScience advances · 2026Article
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- Monocyte-regulated interleukin 12 production drives clearance of Staphylococcus aureus.PLoS pathogens · 2024Article
- High-Frequency Repetitive Magnetic Stimulation Activates Bactericidal Activity of Macrophages via Modulation of p62/Keap1/Nrf2 and p38 MAPK Pathways.Antioxidants (Basel, Switzerland) · 2023Article
- Time-Course Transcriptome Analysis of the Lungs of Mice Challenged with Aerosols of Methicillin-ResistantBiomolecules · 2023Article
- The Influence of Antibiotic Resistance on Innate Immune Responses toAntibiotics (Basel, Switzerland) · 2022Review
- Staphylococcus aureus specific lung resident memory CD4Mucosal immunology · 2022Article
- Diversity of Macrophages in Lung Homeostasis and Diseases.Frontiers in immunology · 2021Review
- The Role of Macrophages inFrontiers in immunology · 2020Review
- Inducible Costimulator Contributes to Methicillin-Resistant Staphylococcus aureus Pneumonia.The Journal of infectious diseases · 2018Article
- CD80/CD86 signaling contributes to the proinflammatory response of Staphylococcus aureus in the airway.Cytokine · 2018Article
- Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence.Cell host & microbe · 2018Article
- S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking.Cell reports · 2018Article
- Neutrophils: Beneficial and Harmful Cells in Septic Arthritis.International journal of molecular sciences · 2018Review
- Humanized Mice Exhibit Increased Susceptibility to Staphylococcus aureus Pneumonia.The Journal of infectious diseases · 2017Article
- Ablation of Pericyte-Like Cells in Lungs by Oropharyngeal Aspiration of Diphtheria Toxin.American journal of respiratory cell and molecular biology · 2017Article
- Role of MicroRNA in the Lung's Innate Immune Response.Journal of innate immunity · 2017Review
- Collaborative Interferon-γ and Interleukin-17 Signaling Protects the Oral Mucosa from Staphylococcus aureus.The American journal of pathology · 2016Article
- Macrophage-epithelial interactions in pulmonary alveoli.Seminars in immunopathology · 2016Review
- Resistance to Acute Macrophage Killing Promotes Airway Fitness of Prevalent Community-Acquired Staphylococcus aureus Strains.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Staphylococcus aureus causes especially severe pulmonary infection, associated with high morbidity and mortality. In addition to the effects of specific virulence factors, it appears that the intensity of the host proinflammatory response, particularly in the initial stages of infection, contributes substantially to pulmonary damage. We tested the hypothesis that the CD11c(+) leukocytes are important in the host response to pulmonary infection with methicillin-resistant S. aureus (MRSA) USA300. Clodronate-induced depletion of the alveolar macrophage population resulted in increased numbers of dendritic cells (DCs) and CD4(+) cells in bronchoalveolar lavage (BAL) fluid and was associated with significantly increased mortality by 18 h following S. aureus inoculation but had no effect on bacterial load or polymorphonuclear leukocyte (PMN) numbers in the lung. These clodronate-treated mice also had increased expression of interleukin-17A/F (IL-17A/F) and CXCL10 but not of gamma interferon (IFN-γ) or tumor necrosis factor (TNF). Depletion of the dendritic cell population in mice expressing a CD11c-enhanced green fluorescent protein (EGFP)-diphtheria toxin receptor (DTR) transgene was associated with an increased bacterial load in the lung but not increased mortality. Both DCs and airway epithelial cells produced CXCL9, -10, and -11 in response to S. aureus. Pretreatment of mice with an anti-CXCR3 antibody prior to inoculation with MRSA substantially reduced CD4(+) cells and decreased pulmonary inflammation at 18 h postinfection compared to pretreatment with an IgG control. The results of these experiments suggest that CD11c(+) cells, the induction of CXCR3 ligand expression, and subsequent CD4(+) cell recruitment have an important role in the pathogenesis of severe MRSA pulmonary infection.
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Registered trials
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