ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2011
Regulation of female reproduction by p53 and its family members.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Pooled it
- Review
- From bench to in silico and backwards: What have we done on genetics of recurrent pregnancy loss and implantation failure and where should we go next?Genetics and molecular biology · 2024Article
- Transcriptome analysis revealed the characteristics and functions of long non-coding RNAs in the hypothalamus during sexual maturation in goats.Frontiers in veterinary science · 2024Article
- Carrying SNP rs17506395 (T > G) inOpen life sciences · 2024Article
- Article
- p63 expression in granulosa-luteinized cells of infertile patients with peritoneal endometriosis submitted to in vitro fertilization.JBRA assisted reproduction · 2022Article
- Genetic variants in the p53 pathway influence implantation and pregnancy maintenance in IVF treatments using donor oocytes.Journal of assisted reproduction and genetics · 2021Article
- The Role of Mutant p63 in Female Fertility.International journal of molecular sciences · 2021Review
- The emerging role of leukemia inhibitory factor in cancer and therapy.Pharmacology & therapeutics · 2021Review
- The TP63 Gene Polymorphism rs17506395 is Associated with Early Breast Cancer in Cameroon.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- The many faces of p53: something for everyone.Journal of molecular cell biology · 2019Review
- The role of p53 in reproduction, an unexpected function for a tumor suppressor.Journal of molecular cell biology · 2019Article
- FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation.PLoS genetics · 2018Article
- Article
- Effects of melatonin administration on embryo implantation and offspring growth in mice under different schedules of photoperiodic exposure.Reproductive biology and endocrinology : RB&E · 2017Article
- Putting p53 in Context.Cell · 2017Review
- The codon 72 polymorphism of p53 influences cell fate following nutrient deprivation.Cancer biology & therapy · 2017Article
- Activating transcription factor 3 promotes embryo attachment via up-regulation of leukemia inhibitory factor in vitro.Reproductive biology and endocrinology : RB&E · 2017Article
- Genome-Wide Association Mapping for Female Infertility in Inbred Mice.G3 (Bethesda, Md.) · 2016Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Tumor suppressor p53 is crucial for embryonic implantation through transcriptional up-regulation of uterine leukemia inhibitory factor (LIF). This article reports that p53 and estrogen receptor α were activated in endometrial tissues during implantation to coordinately regulate LIF production. By using human p53 knockin (Hupki) mice carrying a single nucleotide polymorphism (SNP) at codon 72 (arginine/proline), the arginine allele was demonstrated to produce higher uterine LIF levels during implantation than the proline allele. In humans, the diversity of haplotypes of the p53 gene has decreased during evolution, because the arginine allele, existing in only a subset of haplotypes, is under positive selection. This observation is consistent with previous results showing that the proline allele is enriched in patients undergoing in vitro fertilization (IVF). Studies with p63- and p73-knockout mice have demonstrated the involvement of p63 and p73 in female reproduction and their roles in egg formation and apoptosis (p63) and spindle checkpoint (p73) in female mice. Here, the role of p63 and p73 in human reproduction was investigated. Selected alleles of SNPs in p63 and p73 genes were enriched in IVF patients. These findings demonstrate that the p53 family members are involved in several steps to regulate female reproduction in mice and humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.