ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2011
The ageing lens and cataract: a model of normal and pathological ageing.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
210 citing papers in PubMed, 5 syntheses or guidelines pooled it, 469 citations in OpenAlex.
- Refractive Error and Eye Health: An Umbrella Review of Meta-Analyses.Frontiers in medicine · 2021Pooled it
- The national and subnational prevalence of cataract and cataract blindness in China: a systematic review and meta-analysis.Journal of global health · 2018Pooled it
- Vitamin E and risk of age-related cataract: a meta-analysis.Public health nutrition · 2015Pooled it
- XRCC1 and XPD genetic polymorphisms and susceptibility to age-related cataract: a meta-analysis.Molecular vision · 2015Pooled it
- A dose-response meta-analysis of dietary lutein and zeaxanthin intake in relation to risk of age-related cataract.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Pooled it
- Chitosan-Coated Quercetin Nanoemulsion Eye Drops for Sustained Ocular Delivery and Protection of Lens Degeneration from Oxidative Stress.ACS omega · 2026Article
- The role of DNMT3B, GSK-3β and GJA3 in lens epithelial cell apoptosis and age-related cataract.BMC ophthalmology · 2026Article
- Human Crystallin Variation and Cataract.Investigative ophthalmology & visual science · 2026Review
- The Mammalian Ocular Lens in Focus: Development, Anatomy, Physiology, Transparency, Biomechanics, and Age-related Challenges.Journal of visualized experiments : JoVE · 2026Review
- The aging eye: navigating molecular mechanisms and innovative interventions.Biogerontology · 2026Review
- Hyperhomocysteinemia as a Common Denominator: Linking Posterior Subcapsular Cataract and Pulmonary Thromboembolism.Cureus · 2026Article
- CT Radiomic Features of the Crystalline Lens and Association with Age, Hypertension and Cerebral White Matter Lesions.Diagnostics (Basel, Switzerland) · 2026Article
- Preventing Age-Related Nuclear Cataract Development - Is Cholesterol the Key?Investigative ophthalmology & visual science · 2026Review
- Melatonin alleviates ferroptosis in lens epithelial cells via regulating METTL14 expression.Iranian journal of basic medical sciences · 2026Article
- Metformin attenuates TBHP-induced oxidative injury in human lens epithelial cells and is associated with SIRT1/FOXO1-related autophagy.PloS one · 2026Article
- Article
- Global, regional, and national cataract burden attributable to household air pollution and smoking (1990-2021) and projection to 2050.Frontiers in public health · 2026Article
- The COPD-driven "lung-eye axis": mechanisms and clinical evidence of ocular disease.Frontiers in medicine · 2026Review
- Association between trouble sleeping and cataract in US adults: a cross-sectional study.Frontiers in medicine · 2026Article
- Chronic Ozone Exposure and Its Role in the Development of Age-Related Cataracts: A Comprehensive Analysis.Environment & health (Washington, D.C.) · 2025Article
150 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cataract is a visible opacity in the lens substance, which, when located on the visual axis, leads to visual loss. Age-related cataract is a cause of blindness on a global scale involving genetic and environmental influences. With ageing, lens proteins undergo non-enzymatic, post-translational modification and the accumulation of fluorescent chromophores, increasing susceptibility to oxidation and cross-linking and increased light-scatter. Because the human lens grows throughout life, the lens core is exposed for a longer period to such influences and the risk of oxidative damage increases in the fourth decade when a barrier to the transport of glutathione forms around the lens nucleus. Consequently, as the lens ages, its transparency falls and the nucleus becomes more rigid, resisting the change in shape necessary for accommodation. This is the basis of presbyopia. In some individuals, the steady accumulation of chromophores and complex, insoluble crystallin aggregates in the lens nucleus leads to the formation of a brown nuclear cataract. The process is homogeneous and the affected lens fibres retain their gross morphology. Cortical opacities are due to changes in membrane permeability and enzyme function and shear-stress damage to lens fibres with continued accommodative effort. Unlike nuclear cataract, progression is intermittent, stepwise and non-uniform.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.