Evidence map›Paper›PMID 21402354›Full record

ArticleCell host & microbe2011

Profaning the ultimate sanctuary: HIV latency in hematopoietic stem cells.

Didier Trono, Flavia Marzetta

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Eliminating the HIV reservoir.Current HIV/AIDS reports · 2012
    Review
  3. Achieving a cure for HIV infection: do we have reasons to be optimistic?The Journal of antimicrobial chemotherapy · 2012
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Didier TronoSchool of Life Sciences and Frontiers in Genetics Program, École Polytechnique FÉdÉrale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: didier.trono@epfl.ch.
Flavia MarzettaSchool of Life Sciences and Frontiers in Genetics Program, École Polytechnique FÉdÉrale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early establishment of a reservoir of latently infected T cells is a sobering obstacle to HIV eradication, in spite of the efficacy of current antiretroviral therapies. That latent proviruses might also hide in multipotent hematopoietic stem cells suggests an even more formidable challenge and potentially has therapeutic implications.

Identifiers

PMID21402354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.