ArticleBiophysical journal2011
Critical and off-critical miscibility transitions in model extracellular and cytoplasmic myelin lipid monolayers.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 0 citations in OpenAlex.
- Adsorption of Myelin Basic Protein on Model Myelin Membranes Reveals Weakening of van der Waals Interactions in a Lipid Ratio-Dependent Manner.Membranes · 2025Article
- Spontaneous evolution of equilibrium morphology in phospholipid-cholesterol monolayers.Science advances · 2022Article
- Adhesion Process of Biomimetic Myelin Membranes Triggered by Myelin Basic Protein.Frontiers in chemistry · 2021Article
- Membrane stiffness and myelin basic protein binding strength as molecular origin of multiple sclerosis.Scientific reports · 2020Article
- Comparison of Line Tension Measurement Methods for Lipid Monolayers at Liquid-Liquid Coexistence.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Interfacial curvature effects on the monolayer morphology and dynamics of a clinical lung surfactant.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Lipid Order Degradation in Autoimmune Demyelination Probed by Polarized Coherent Raman Microscopy.Biophysical journal · 2017Article
- Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line.Scientific reports · 2017Article
- Article
- Oligodendroglial membrane dynamics in relation to myelin biogenesis.Cellular and molecular life sciences : CMLS · 2016Review
- Visualizing monolayers with a water-soluble fluorophore to quantify adsorption, desorption, and the double layer.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Lipid domains control myelin basic protein adsorption and membrane interactions between model myelin lipid bilayers.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Myelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoforms.Journal of neurochemistry · 2013Review
- Adhesion and hemifusion of cytoplasmic myelin lipid membranes are highly dependent on the lipid composition.Biochimica et biophysica acta · 2012Article
- Lipid-protein interactions alter line tensions and domain size distributions in lung surfactant monolayers.Biophysical journal · 2012Article
- Self-segregation of myelin membrane lipids in model membranes.Biophysical journal · 2011Article
- Relating domain size distribution to line tension and molecular dipole density in model cytoplasmic myelin lipid monolayers.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Monolayers based on the composition of the cytoplasmic (CYT) or extracellular (EXT) sides of the myelin bilayer form coexisting immiscible liquid phases similar to the liquid-ordered/liquid-disordered phases in phospholipid/cholesterol monolayers. Increasing the temperature or surface pressure causes the two liquid phases to mix, although in significantly different fashion for the CYT and EXT monolayers. The cerebroside-rich EXT monolayer is near a critical composition and the domains undergo coalescence and a circle-to-stripe transition along with significant roughening of the domain boundaries before mixing. The phase transition in the cerebroside-free cytoplasmic side occurs abruptly without domain coalescence; hence, the cytoplasmic monolayer is not near a critical composition, although the domains exhibit shape instabilities within 1-2 mN/m of the transition. The change in mixing pressure decreases significantly with temperature for the EXT monolayer, with dΠ(crit)/dT ∼ 1.5 mN/m/°C, but the mixing pressure of the CYT monolayer varies little with temperature. This is due to the differences in the nonideality of cholesterol interactions with cerebrosides (EXT) relative to phospholipids (CYT). EXT monolayers based on the composition of white matter from marmosets with experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis, remain phase-separated at higher surface pressures than control, while EAE CYT monolayers are similar to control. Myelin basic protein, when added to the CYT monolayer, increases lipid miscibility in CYT monolayers; likely done by altering the dipole density difference between the two phases.
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