ArticleBiophysical journal2011
Analysis of molecular diffusion by first-passage time variance identifies the size of confinement zones.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Photophysics of Organic Fluorophore Photobluing and Its Applications in Fluorescence and Super-Resolution Microscopy.Accounts of chemical research · 2026Article
- Precise Detection and Visualization of Nanoscale Temporal Confinement in Single-Molecule Tracking Analysis.Membranes · 2022Article
- Simulation of receptor triggering by kinetic segregation shows role of oligomers and close contacts.Biophysical journal · 2022Article
- Detecting Transient Trapping from a Single Trajectory: A Structural Approach.Entropy (Basel, Switzerland) · 2021Article
- Neuraminidase-3 Is a Negative Regulator of LFA-1 Adhesion.Frontiers in chemistry · 2019Article
- A Hidden Markov Model for Detecting Confinement in Single-Particle Tracking Trajectories.Biophysical journal · 2018Article
- A Simple and Powerful Analysis of Lateral Subdiffusion Using Single Particle Tracking.Biophysical journal · 2017Article
- Limitations of Qdot labelling compared to directly-conjugated probes for single particle tracking of B cell receptor mobility.Scientific reports · 2017Article
- Article
- Anomalous versus slowed-down Brownian diffusion in the ligand-binding equilibrium.Biophysical journal · 2013Article
- Bayesian approach to MSD-based analysis of particle motion in live cells.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The diffusion of receptors within the two-dimensional environment of the plasma membrane is a complex process. Although certain components diffuse according to a random walk model (Brownian diffusion), an overwhelming body of work has found that membrane diffusion is nonideal (anomalous diffusion). One of the most powerful methods for studying membrane diffusion is single particle tracking (SPT), which records the trajectory of a label attached to a membrane component of interest. One of the outstanding problems in SPT is the analysis of data to identify the presence of heterogeneity. We have adapted a first-passage time (FPT) algorithm, originally developed for the interpretation of animal movement, for the analysis of SPT data. We discuss the general application of the FPT analysis to molecular diffusion, and use simulations to test the method against data containing known regions of confinement. We conclude that FPT can be used to identify the presence and size of confinement within trajectories of the receptor LFA-1, and these results are consistent with previous reports on the size of LFA-1 clusters. The analysis of trajectory data for cell surface receptors by FPT provides a robust method to determine the presence and size of confined regions of diffusion.
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