ArticleBiophysical journal2011
Acyl-chain methyl distributions of liquid-ordered and -disordered membranes.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Harnessing Membrane-Active Peptides for Selective Cancer Targeting: Phosphatidylserine Recognition by Tilapia Piscidin 4.JACS Au · 2026Article
- Effect of a scramblase activator upon lipid and probe scrambling and membrane domain formation in HEK 293T cells.Faraday discussions · 2025Article
- Neutron spin echo shows pHLIP is capable of retarding membrane thickness fluctuations.Biochimica et biophysica acta. Biomembranes · 2024Article
- Antiviral activity of the host defense peptide piscidin 1: investigating a membrane-mediated mode of action.Frontiers in chemistry · 2024Article
- Understanding the Mechanical Properties of Ultradeformable Liposomes Using Molecular Dynamics Simulations.The journal of physical chemistry. B · 2023Article
- Wrapping anisotropic microgel particles in lipid membranes: Effects of particle shape and membrane rigidity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- DOTAP: Structure, hydration, and the counterion effect.Biophysical journal · 2023Article
- Lipid/water interface of galactolipid bilayers in different lyotropic liquid-crystalline phases.Frontiers in molecular biosciences · 2022Article
- Copper-binding anticancer peptides from the piscidin family: an expanded mechanism that encompasses physical and chemical bilayer disruption.Scientific reports · 2021Article
- Characterization of the Features of Water Inside the SecY Translocon.The Journal of membrane biology · 2021Review
- How We Came to Understand the "Tumultuous Chemical Heterogeneity" of the Lipid Bilayer Membrane.The Journal of membrane biology · 2020Review
- The host-defense peptide piscidin P1 reorganizes lipid domains in membranes and decreases activation energies in mechanosensitive ion channels.The Journal of biological chemistry · 2019Article
- Magainin 2 and PGLa in Bacterial Membrane Mimics I: Peptide-Peptide and Lipid-Peptide Interactions.Biophysical journal · 2019Article
- Application of small-angle neutron diffraction to the localization of general anesthetics in model membranes.European biophysics journal : EBJ · 2019Article
- Structure and Function in Antimicrobial Piscidins: Histidine Position, Directionality of Membrane Insertion, and pH-Dependent Permeabilization.Journal of the American Chemical Society · 2019Article
- Assembling responsive microgels at responsive lipid membranes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region.Toxins · 2017Article
- Thickness Mismatch of Coexisting Liquid Phases in Noncanonical Lipid Bilayers.The journal of physical chemistry. B · 2016Article
- Interleaflet mixing and coupling in liquid-disordered phospholipid bilayers.Biochimica et biophysica acta · 2016Article
- There Is No Simple Model of the Plasma Membrane Organization.Frontiers in cell and developmental biology · 2016Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
A central feature of the lipid raft concept is the formation of cholesterol-rich lipid domains. The introduction of relatively rigid cholesterol molecules into fluid liquid-disordered (L(d)) phospholipid bilayers can produce liquid-ordered (L(o)) mixtures in which the rigidity of cholesterol causes partial ordering of the flexible hydrocarbon acyl chains of the phospholipids. Several lines of evidence support this concept, but direct structural information about L(o) membranes is lacking. Here we present the structure of L(o) membranes formed from cholesterol and dioleoylphosphatidylcholine (DOPC). Specific deuteration of the DOPC acyl-chain methyl groups and neutron diffraction measurements reveal an extraordinary disorder of the acyl chains of neat L(d) DOPC bilayers. The disorder is so great that >20% of the methyl groups are in intimate contact with water in the bilayer interface. The ordering of the DOPC acyl chains by cholesterol leads to retraction of the methyl groups away from the interface. Molecular dynamics simulations based on experimental systems reveal asymmetric transbilayer distributions of the methyl groups associated with each bilayer leaflet.
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