Evidence map›Paper›PMID 21401992›Full record

ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2011

'They won't do any harm and might do some good': time to think again on the use of antidepressants?

Hugh Middleton, Joanna Moncrieff

Abstract read
In one paragraph

Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Conflict in Men's Experiences With Antidepressants.American journal of men's health · 2018
    Article
  10. Article
  11. Antidepressants are not overprescribed for mild depression.The Journal of clinical psychiatry · 2015
    Article
  12. Has evidence-based medicine left quackery behind?Internal and emergency medicine · 2015
    Article
  13. Improving Access to Psychological Therapies and antidepressant prescribing rates in England: a longitudinal time-series analysis.The British journal of general practice : the journal of the Royal College of General Practitioners · 2013
    Article
  14. Article
  15. Article
  16. Review
  17. An end to depression in primary care?The British journal of general practice : the journal of the Royal College of General Practitioners · 2012
    Article
  18. Antidepressant prescribing.The British journal of general practice : the journal of the Royal College of General Practitioners · 2011
    Article
  19. Antidepressant prescribing.The British journal of general practice : the journal of the Royal College of General Practitioners · 2011
    Article
  20. Prescribing antidepressants for depression: time to be dimensional and inclusive.The British journal of general practice : the journal of the Royal College of General Practitioners · 2011
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Hugh MiddletonSchool of Sociology and Social Policy, University of Nottingham, Nottingham. Hugh.middleton@nottingham.ac.uk
Joanna Moncrieff

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite NICE guidance that should have limited it, antidepressant prescribing continues to increase. Research evidence suggests that much if not all of the observed efficacy should be attributed to complex non-specific effects rather than 'restoration of disturbed brain chemistry'. According to this view the uncertain benefits of antidepressants are unlikely to outweigh the risks, suggesting the need to explore other approaches to treatment.

Indexed as

Antidepressive AgentsDepressive DisorderHumansPractice Patterns, Physicians'Antidepressive Agents

Identifiers

PMID21401992
PMCPMC3020050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.