ArticleBMC infectious diseases2011
Human rhinovirus infection in young African children with acute wheezing.
Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Prevalence and Molecular Epidemiology of Human Coronaviruses in Africa Prior to the SARS-CoV-2 Outbreak: A Systematic Review.Viruses · 2023Pooled it
- Prevalence of respiratory viruses using polymerase chain reaction in children with wheezing, a systematic review and meta-analysis.PloS one · 2020Pooled it
- Can we distinguish respiratory viral infections based on clinical features? A prospective pediatric cohort compared to systematic literature review.Reviews in medical virology · 2018Pooled it
- Respiratory Pathogen Detection Among Febrile Inpatients in Northern Tanzania, 2016-2019.Open forum infectious diseases · 2026Article
- CIRCULATING VIRAL RESPIRATORY PATHOGENS AS CAUSATIVE AGENT FOR SEVERE ACUTE RESPIRATORY INFECTIONS IN MOROCCO: A SYSTEMATIC REVIEW.African journal of infectious diseases · 2025Article
- Comparison of immune response to human rhinovirus C and respiratory syncytial virus in highly differentiated human airway epithelial cells.Virology journal · 2022Article
- Derivation and validation of a novel risk assessment tool to identify children aged 2-59 months at risk of hospitalised pneumonia-related mortality in 20 countries.BMJ global health · 2022Article
- Epidemiology of acute respiratory viral infections in children in Vientiane, Lao People's Democratic Republic.Journal of medical virology · 2021Article
- Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study.Viruses · 2021Article
- A prospective case-control study on the association of Rhinovirus nasopharyngeal viral load and viremia in South African children hospitalized with severe pneumonia.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020Article
- Genotypic diversity, circulation patterns and co-detections among rhinoviruses in Queensland, 2001.Access microbiology · 2020Article
- Molecular Subtyping of Human Rhinovirus in Children from Three Sub-Saharan African Countries.Journal of clinical microbiology · 2019Article
- Virologic study of acute lower respiratory tract infections in children admitted to the paediatric department of Blida University Hospital, Algeria.New microbes and new infections · 2019Article
- An Intensive, Active Surveillance Reveals Continuous Invasion and High Diversity of Rhinovirus in Households.The Journal of infectious diseases · 2019Article
- Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda.PloS one · 2019Article
- Prevalence of Human rhinovirus infection in young children with acute wheezing.The Gazette of the Egyptian Paediatric Association · 2018Article
- Rhinovirus C is associated with wheezing and rhinovirus A is associated with pneumonia in hospitalized children in Morocco.Journal of medical virology · 2017Article
- Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique.Tropical medicine & international health : TM & IH · 2016Article
- Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Article
- Human Rhinovirus B and C Genomes from Rural Coastal Kenya.Genome announcements · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfections caused by human rhinoviruses (HRVs) are important triggers of wheezing in young children. Wheezy illness has increasingly been recognised as an important cause of morbidity in African children, but there is little information on the contribution of HRV to this. The aim of this study was to determine the role of HRV as a cause of acute wheezing in South African children.
methodsTwo hundred and twenty children presenting consecutively at a tertiary children's hospital with a wheezing illness from May 2004 to November 2005 were prospectively enrolled. A nasal swab was taken and reverse transcription PCR used to screen the samples for HRV. The presence of human metapneumovirus, human bocavirus and human coronavirus-NL63 was assessed in all samples using PCR-based assays. A general shell vial culture using a pool of monoclonal antibodies was used to detect other common respiratory viruses on 26% of samples. Phylogenetic analysis to determine circulating HRV species was performed on a portion of HRV-positive samples. Categorical characteristics were analysed using Fisher's Exact test.
resultsHRV was detected in 128 (58.2%) of children, most (72%) of whom were under 2 years of age. Presenting symptoms between the HRV-positive and negative groups were similar. Most illness was managed with ambulatory therapy, but 45 (35%) were hospitalized for treatment and 3 (2%) were admitted to intensive care. There were no in-hospital deaths. All 3 species of HRV were detected with HRV-C being the most common (52%) followed by HRV-A (37%) and HRV-B (11%). Infection with other respiratory viruses occurred in 20/128 (16%) of HRV-positive children and in 26/92 (28%) of HRV-negative samples.
conclusionHRV may be the commonest viral infection in young South African children with acute wheezing. Infection is associated with mild or moderate clinical disease.
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