SynthesisAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2011
Risk of window period hepatitis-C infection in high infectious risk donors: systematic review and meta-analysis.
Synthesis in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Donor heart selection: Evidence-based guidelines for providers.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Guideline
- Guidelines for the assessment and acceptance of potential brain-dead organ donors.Revista Brasileira de terapia intensiva · 2016Guideline
- The Impact of Critical Care Quarantine on the Residual Risk of Unexpected Organ Donor Blood-borne Virus Infection.Transplantation direct · 2025Article
- Increased Infectious Risk Donor Status and Equity-Relevant Predictors of Organ Donation Organization Approach and Caregiver Consent for Deceased Organ Donation in a Canadian Province (2015-2021).Clinical transplantation · 2024Observational
- To decline or not to decline: Consequences of decision-making regarding lung offers from donors with hepatitis C.The Journal of thoracic and cardiovascular surgery · 2024Article
- Recently Acquired Blood-borne Virus Infections in Australian Deceased Organ Donors: Estimation of the Residual Risk of Unexpected Transmission.Transplantation direct · 2023Article
- Outcome of Kidney Transplants from Viremic and Non-Viremic Hepatitis C Virus Positive Donors into Negative Recipients: Results of the Spanish Registry.Journal of clinical medicine · 2023Article
- Review of heart transplantation from hepatitis C-positive donors.World journal of transplantation · 2022Review
- Utilization of HCV viremic donors in kidney transplantation: a chance or a threat?Renal failure · 2022Review
- Consent to organ offers from public health service "Increased Risk" donors decreases time to transplant and waitlist mortality.BMC medical ethics · 2022Article
- Deceased Donor Characteristics and Kidney Transplant Outcomes.Transplant international : official journal of the European Society for Organ Transplantation · 2022Review
- Correlation between serology and nucleic acid amplification test in blood donors who are reactive for hepatitis B virus, hepatitis C and human immunodeficiency virus and evaluation of the epidemiological profile of infected people in blood centers in the State of Paraná.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021Article
- Donor management using a specialized donor care facility is associated with higher organ utilization from drug overdose donors.Clinical transplantation · 2021Article
- Liver Transplant From Increased-Risk Donors in the Era of Direct-Acting Antivirals for Hepatitis C.Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2020Article
- Brief Report: Willingness to Accept HIV-Infected and Increased Infectious Risk Donor Organs Among Transplant Candidates Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Strategies to Expand the Deceased Donor Pool for Pediatric Kidney Transplant Recipients.Kidney360 · 2020Article
- Increased-risk donors and solid organ transplantation: current practices and opportunities for improvement.Current opinion in organ transplantation · 2020Review
- Utilisation of kidneys from deceased donors at increased risk of infectious disease transmission: a step in the right direction.Pediatric nephrology (Berlin, Germany) · 2020Article
- Outcomes After Declining Increased Infectious Risk Kidney Offers for Pediatric Candidates in the United States.Transplantation · 2019Article
- National Variation in Increased Infectious Risk Kidney Offer Acceptance.Transplantation · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The OPTN classifies high infectious risk donors (HRDs) based on criteria originally intended to identify people at risk for HIV infection. These donors are sometimes referred to as 'CDC high risk donors' in reference to the CDC-published guidelines adopted by the OPTN. However, these guidelines are also being used to identify deceased donors at increased risk of window period (WP) hepatitis C virus (HCV) infection, although not designed for this purpose. The actual risk of WP HCV infection in HRDs is unknown. We performed a systematic review of 3476 abstracts and identified 37 eligible estimates of HCV incidence in HRD populations in the United States/Canada. Pooled HCV incidence was derived and used to estimate the risk of WP infection for each HRD category. Risks ranged from 0.26 to 300.6 per 10,000 donors based on WP for ELISA and 0.027 to 32.4 based on nucleic acid testing (NAT). Injection drug users were at highest risk (32.4 per 10,000 donors by NAT WP), followed by commercial sex workers and donors exhibiting high risk sexual behavior (12.3 per 10,000), men who have sex with men (3.5 per 10,000), incarcerated donors (0.8 per 10,000), donors exposed to HIV infected blood (0.4 per 10,000) and hemophiliacs (0.027 per 10,000). NAT reduced WP risk by approximately 10-fold in each category.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.