ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2011
Association of HLA polymorphisms with post-transplant lymphoproliferative disorder in solid-organ transplant recipients.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Tabelecleucel for EBV+ PTLD after allogeneic HCT or SOT in a multicenter expanded access protocol.Blood advances · 2024Trial
- Posttransplant rituximab exposure and risk of PTLD in solid organ transplant recipients with EBV DNAemia.Blood neoplasia · 2025Article
- Acute-Onset Posttransplant Lymphoproliferative Disorder After Kidney Transplant.Kidney medicine · 2025Article
- Histopathological characteristics of Epstein-Barr virus (EBV)-associated encephalitis and colitis in chronic active EBV infection.Journal of pathology and translational medicine · 2025Article
- Analysis of HLA Alleles in Different Cohorts of Patients Infected byInternational journal of molecular sciences · 2024Article
- Article
- Case Report: Post-transplant lymphoproliferative disorder as a serious complication of vascularized composite allotransplantation.Frontiers in transplantation · 2024Article
- EBV Reactivation and Lymphomagenesis: More Questions than Answers.Current hematologic malignancy reports · 2023Review
- Molecular profiling identifies at least 3 distinct types of posttransplant lymphoproliferative disorder involving the CNS.Blood advances · 2023Article
- Case Report: Non-negligible Epstein-Barr virus-associated posttransplant lymphoproliferative disorders in a lung transplant recipient.Frontiers in immunology · 2023Article
- Post-transplant Lymphoproliferative Disorder Following Cardiac Transplantation.Frontiers in cardiovascular medicine · 2022Review
- Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: Analysis of ISHLT Registry.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2020Article
- A role for human leucocyte antigens in the susceptibility to SARS-Cov-2 infection observed in transplant patients.International journal of immunogenetics · 2020Article
- Epstein-Barr virus-related post-transplant lymphoproliferative disease (EBV-PTLD) in the setting of allogeneic stem cell transplantation: a comprehensive review from pathogenesis to forthcoming treatment modalities.Bone marrow transplantation · 2020Review
- Biological Difference Between Epstein-Barr Virus Positive and Negative Post-transplant Lymphoproliferative Disorders and Their Clinical Impact.Frontiers in oncology · 2020Review
- Posttransplantation lymphoproliferative disorder after pediatric solid organ transplantation: experiences of 20 years in a single center.Korean journal of pediatrics · 2017Article
- Emerging insights on the pathogenesis and treatment of extranodal NK/T cell lymphomas (ENKTL).Discovery medicine · 2017Review
- HLA and Risk of Diffuse Large B cell Lymphoma After Solid Organ Transplantation.Transplantation · 2016Article
- Matched-pair analysis: identification of factors with independent influence on the development of PTLD after kidney or liver transplantation.Transplantation research · 2016Article
- Posttransplant lymphoproliferative disorders following liver transplantation: Where are we now?World journal of gastroenterology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The association between HLA polymorphisms and PTLD was investigated in a case-control study, comparing 110 predominantly adult solid-organ transplant recipients who developed PTLD to 5601 who did not. Donor and recipient HLA were analyzed. We detected a significant association between recipient HLA-A26 and the development of PTLD (OR 2.74; p = 0.0007). In Caucasian recipients, both recipient and donor HLA-A26 were independently associated with development of PTLD (recipient A26 OR 2.99; p = 0.0004, donor A26 OR 2.81; p = 0.002). Analysis of HLA-A and -B haplotypes revealed that recipient HLA-A26, B38 haplotype was strongly correlated with a higher incidence of EBV-positive PTLD (OR 3.99; p = 0.001). The common ancestral haplotype HLA-A1, B8, DR3, when carried by the donor, was protective against PTLD (OR 0.41; p = 0.05). Several other HLA specificities demonstrated associations with clinical and pathological characteristics as well as survival. These findings demonstrate the importance of HLA polymorphisms in modulating the risk for PTLD, and may be useful in risk stratification and development of monitoring and prophylaxis strategies.
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