ArticleJournal of agricultural and food chemistry2011
Resveratrol metabolites do not elicit early pro-apoptotic mechanisms in neuroblastoma cells.
Article in Journal of agricultural and food chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Focus on the Use of Resveratrol in Bladder Cancer.International journal of molecular sciences · 2023Review
- Gut Microbiota-Derived Resveratrol Metabolites, Dihydroresveratrol and Lunularin, Significantly Contribute to the Biological Activities of Resveratrol.Frontiers in nutrition · 2022Article
- Chemo-Preventive Action of Resveratrol: Suppression of p53-A Molecular Targeting Approach.Molecules (Basel, Switzerland) · 2021Review
- Metabolic profile and structure-activity relationship of resveratrol and its analogs in human bladder cancer cells.Cancer management and research · 2019Article
- Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target.Molecules (Basel, Switzerland) · 2017Review
- Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration.Journal of neurosurgery · 2017Article
- Examination of Gossypol-Pluronic Micelles as Potential Radiosensitizers.The AAPS journal · 2015Article
- Amino Acid Carbamates As Prodrugs Of Resveratrol.Scientific reports · 2015Article
- Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution?Molecules (Basel, Switzerland) · 2014Review
- Analytical method development for synthesized conjugated metabolites of trans-resveratrol, and application to pharmacokinetic studies.Journal of pharmaceutical and biomedical analysis · 2012Article
- Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model.International journal of oncology · 2012Article
- A nondenatured, noncrosslinked collagen matrix to deliver stem cells to the heart.Regenerative medicine · 2011Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
Resveratrol, a nontoxic polyphenol, has been shown to inhibit tumor growth in a xenograft mouse model of neuroblasoma. However, resveratrol is rapidly metabolized, mainly to its glucuronidated and sulfated derivatives. This study demonstrates that resveratrol alone, and not the glucuronidated or sulfated metabolites, is taken up into tumor cells, induces a rise in [Ca(2+)](i), and ultimately leads to a decrease in tumor cell viability. A new water-soluble resveratrol formulation was delivered directly at the site of the tumor in a neuroblastoma mouse model. The amount of unmodified resveratrol associated with the tumor increased more than 1000-fold. The increase of unmodified resveratrol associated with the tumor resulted in tumor regression. The number of residual tumor cells that remained viable also decreased as the ratio of the metabolites relative to unmodified resveratrol declined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.