SynthesisHeart failure reviews2011
Pharmacological therapies for the prevention of acute kidney injury following cardiac surgery: a systematic review.
Synthesis in Heart failure reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- The Society of Thoracic Surgeons/Society of Cardiovascular Anesthesiologists/American Society of Extracorporeal Technology Clinical Practice Guidelines for the Prevention of Adult Cardiac Surgery-Associated Acute Kidney Injury.The journal of extra-corporeal technology · 2022Guideline
- Pharmacological interventions for the prevention of renal injury in surgical patients: a systematic literature review and meta-analysis.British journal of anaesthesia · 2021Pooled it
- N-acetylcysteine use among patients undergoing cardiac surgery: A systematic review and meta-analysis of randomized trials.PloS one · 2019Pooled it
- Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 : Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine.Intensive care medicine · 2017Pooled it
- Trial
- Systemic inflammation and oxidative stress contribute to acute kidney injury after transcatheter aortic valve implantation.Cardiology journal · 2022Article
- Case report: effect of umbilical cord mesenchymal stem cells on immunoglobulin A nephropathy after acute renal failure.American journal of translational research · 2022Article
- Rationale and Design of Assessing the Effectiveness of Short-Term Low-Dose Lithium Therapy in Averting Cardiac Surgery-Associated Acute Kidney Injury: A Randomized, Double Blinded, Placebo Controlled Pilot Trial.Frontiers in medicine · 2021Article
- Epidemiology, outcomes, and management of acute kidney injury in the vascular surgery patient.Journal of vascular surgery · 2018Review
- Acute kidney injury after cardiac surgery: a preventable event?Journal of anesthesia · 2017Article
- A Phase I study to determine the pharmacokinetic profile, safety and tolerability of sildenafil (RevatioBritish journal of clinical pharmacology · 2017Article
- Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies).Annals of intensive care · 2016Review
- A word of caution on renal risks of prothrombin complex concentrate use in cardiac surgery.Critical care (London, England) · 2016Article
- Prediction and Prevention of Acute Kidney Injury after Cardiac Surgery.BioMed research international · 2016Review
- Prevention and Treatment of Cardiac Surgery Associated Acute Kidney Injury.Journal of anesthesia and perioperative medicine · 2016Article
- Acute Kidney Injury in the Surgical Patient.Critical care clinics · 2015Review
- Acute kidney injury following surgical aortic valve replacement.Journal of cardiac surgery · 2015Article
- Chronic kidney disease in congenital heart disease patients: a narrative review of evidence.Canadian journal of kidney health and disease · 2015Review
- Serum creatinine role in predicting outcome after cardiac surgery beyond acute kidney injury.World journal of cardiology · 2014Review
- A patient with AKI after cardiac surgery.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Post-cardiac surgery acute kidney injury (AKI) is common and is associated with a significant increase in morbidity and mortality. We aimed to systematically review randomised trials that assessed the renoprotective utility of pharmacological agents in patients undergoing cardiac surgery. We searched PubMed, Embase and the Cochrane Central Register of Controlled Trials for randomised controlled trials comparing renoprotective pharmacological interventions with control in adult patients undergoing cardiac surgery with cardiopulmonary bypass. We extracted data for mortality, need for renal replacement therapy (RRT), incidence of AKI, and creatinine clearance at 24-48 h. About 49 randomised controlled trials involving 4605 patients were included. Pharmacological interventions included dopamine, fenoldopam, calcium channel antagonists, natriuretic peptides, diuretics, and N-acetylcysteine. Most trials were of poor quality, with small sample sizes, under-reporting of randomisation procedure, allocation concealment and method of blinding. No pharmacological intervention significantly reduced mortality. Fenoldopam and Atrial Natriuretic Peptide (ANP) reduced the need for renal replacement therapy by 5% (NNT 20, 95% CI 11.3, 83.0) and 3.5% (NNT 29, 95% CI 17.1, 84.4), respectively. Brain Natriuretic Peptide resulted in a 10% reduction in the incidence of AKI (NNT 11, 95% CI 6.2, 32.0). Dopamine caused a significant reduction in creatinine clearance (-4.26 ml/min, 95% CI -7.14, -1.39). The quality of studies that have assessed pharmacological renoprotective agents in cardiac surgery is generally poor. Fenoldopam, ANP and BNP show evidence of renoprotection. Randomised studies evaluating the effect of novel renoprotective agents that are powered to detect clinically relevant differences in outcomes are required.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.