Evidence map›Paper›PMID 21400226›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2011

Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study.

Laura Kranaster, Jutta Kammerer-Ciernioch, Carolin Hoyer, Alexander Sartorius

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02305394 (Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy ---a Randomized Control Double-Blind Clinical Trial), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02305394 phase4unknown statusnot on this mapstarted 2015, after this paper: background citation

Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy ---a Randomized Control Double-Blind Clinical Trial

TypeinterventionalSponsorFirst Affiliated Hospital of Chongqing Medical UniversityRan2015 to 2017Enrolled132ConditionsDepressive Symptoms, Impaired Cognition, Electroconvulsive TherapyArmsketamine and propofol, propofol and normal saline
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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  13. Electroconvulsive therapy (ECT) with ketamine induction for catatonia in an HIV positive patient.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Laura KranasterDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Ruprecht-Karls-University Heidelberg, J5, 68159 Mannheim, Germany.
Jutta Kammerer-Ciernioch
Carolin Hoyer
Alexander Sartorius
Heidelberg University · DECentral Institute of Mental Health · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a retrospective chart review, we examined the effects of ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, as electroconvulsive therapy (ECT) anaesthetic in patients suffering from therapy-resistant depression. We included 42 patients who received ECT treatment with either ketamine (n = 16) or the barbiturate thiopental (n = 26). We analysed the number of sessions until completion of ECT treatment (used as a surrogate parameter for outcome), psychopathology as assessed by pre- and post-ECT Mini-Mental State Examination (MMSE) and Hamilton Rating Scale for Depression (HAM-D) scores as well as ECT and seizure parameters (stimulation dose, seizure duration and concordance, urapidil dosage for post-seizure blood pressure management). The ketamine group needed significantly fewer ECT sessions and had significantly lower HAM-D and higher MMSE scores afterwards. As expected, the ketamine group needed more urapidil for blood pressure control. Taking into account the limits inherent in a retrospective study design and the rather small sample size, our results nonetheless point towards synergistic effects of ECT and ketamine anaesthesia, less cognitive side effects and good tolerability of ketamine.

Indexed as

Anesthetics, DissociativeKetamineAgedAnesthetics, IntravenousAntihypertensive AgentsCognition DisordersDepressive Disorder, Treatment-ResistantElectroconvulsive TherapyElectroencephalographyFemaleHumansInpatientsMajor Depressive DisorderMaleMiddle AgedNeuropsychological TestsAnesthetics, DissociativeAnesthetics, IntravenousAntihypertensive AgentsKetaminePiperazinesThiopentalurapidil

Identifiers

PMID21400226
OpenAlexW1998222115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.