ArticleInflammation2012
The burn wound inflammatory response is influenced by midazolam.
Article in Inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Association between anesthetics and the postoperative pneumonia risk in patients with non-traumatic subarachnoid hemorrhage: an analysis of the MIMIC-IV database.Frontiers in neurology · 2025Article
- Sleep Immune Cross Talk and Insomnia.Advances in experimental medicine and biology · 2023Review
- Midazolam's Effects on Delayed-Rectifier KInternational journal of molecular sciences · 2021Article
- Associations between anxiolytic medications and ventral hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2018Article
- Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction.Molecules (Basel, Switzerland) · 2018Review
- Heterogeneity of mast cells and expression of Annexin A1 protein in a second degree burn model with silver sulfadiazine treatment.PloS one · 2017Article
- The extracellular matrix protein matrilin-2 induces post-burn inflammatory responses as an endogenous danger signal.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Silver sulfadiazine retards wound healing in mice via alterations in cytokine expression.The Journal of investigative dermatology · 2015Article
- Effects of fentanyl, midazolam and their combination on immune function and mortality in mice with sepsis.Experimental and therapeutic medicine · 2015Article
- Adipose inflammation and macrophage infiltration after binge ethanol and burn injury.Alcoholism, clinical and experimental research · 2014Article
- Ultrasonic incisions produce less inflammatory mediator response during early healing than electrosurgical incisions.PloS one · 2013Article
- Wound-healing and benzodiazepines: does sleep play a role in this relationship?Clinics (Sao Paulo, Brazil) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burn patients requiring hospitalization are often treated for anxiety with benzodiazepines (BDZs). Benzodiazepines are reported to influence immune system function. Immune system alterations are a major cause of burn-induced mortality. We wanted to determine whether the BDZ, midazolam given daily at an anxiolytic dose, had any influence on the burn injury-induced inflammatory response in the blood and wound. Mice received a 15% total body surface area flame burn and received either midazolam 1 mg/kg i.p. or saline 0.1 ml daily. Blood and skin wounds were harvested 24 h after injection on post-burn day 2, 3, 7, or 8. Mice treated with midazolam had significantly lower serum IL-1β (p=0.002), TNF-α (p=0.002), IL-6 (p=0.016), IL-10 (p=0.009), and TGF-β (p=0.004) than saline-treated mice, with little impact on serum chemokine levels. In the wound, TNF-α and IL-10 were the only cytokines significantly influenced by the drug, being lower (p=0.018) and higher (p=0.006), respectively. The chemokines in the wound influenced significantly by midazolam were MIP-1α, MIP-1β, and MIP-2 while MCP-1 and KC were not. There were more inflammatory cells at the burn wound margin in midazolam-treated mice on post-burn day 3. Although serum nitrate/nitrite was significantly increased by midazolam (p=0.03), both eNOS and iNOS mRNA expression in the wound were similar to the saline group. We found that midazolam given daily after burn injury significantly influenced the inflammatory response. The clinical implications of these findings on wound healing and shock following burn injury, especially larger burns, deserve further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.