ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 74 citations in OpenAlex.
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- A GC-MS Chemotaxonomic Study on Lipophilic Compounds in the Bark ofMetabolites · 2023Article
- α-Amyrin and β-Amyrin Isolated fromMolecules (Basel, Switzerland) · 2021Article
- Enhancing hygroscopic stability of agave fructans capsules obtained by electrospraying.Journal of food science and technology · 2021Article
- Chemical characterization and anti-arthritic appraisal of Monotheca buxifolia methanolic extract in Complete Freund's Adjuvant-induced arthritis in Wistar rats.Inflammopharmacology · 2021Article
- α,β-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Leishmanicidal, Trypanocidal and Antioxidant Activity of Amyrin-Rich Extracts fromIranian journal of pharmaceutical research : IJPR · 2020Article
- Use of emerging technologies in the extraction of lupeol, α-amyrin and β-amyrin from sea grape (Journal of food science and technology · 2018Article
- The triterpenoid alpha, beta-amyrin prevents the impaired aortic vascular reactivity in high-fat diet-induced obese mice.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma.Acta biochimica et biophysica Sinica · 2014Review
- Ethnopharmacological Significance of Eclipta alba (L.) Hassk. (Asteraceae).International scholarly research notices · 2014Review
- Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.Anti-cancer agents in medicinal chemistry · 2012Review
- The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors.British journal of pharmacology · 2012Article
- Antihyperglycemic and hypolipidemic effects of α, β-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice.Lipids in health and disease · 2012Article
- Anti-hyperglycemic, lipid-lowering, and anti-obesity effects of the triterpenes α and β-amyrenonesAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the anti-inflammatory effect of α,β-amyrin, a pentacyclic triterpenoid from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice.
methodsAcute pancreatitis was induced in Swiss mice by five intraperitoneal injections of cerulein (50 μg/kg), at 1 h intervals. Mice received α,β-amyrin (10, 30 and 100 mg/kg), thalidomide (200 mg/kg), or vehicle (3% Tween 80) orally 1 h before and 12 h after the cerulein challenge. The severity of pancreatitis was evaluated 24 h after cerulein by assessing serum pro-inflammatory cytokines and amylase activity, pancreatic myeloperoxidase (MPO), and thiobarbituric acid-reactive substances (TBARS), as well as by histology.
resultsα,β-Amyrin and thalidomide significantly attenuated the cerulein-induced increase in tumor necrosis factor (TNF)-α, interleukin-6, lipase, amylase, MPO, and TBARS. Moreover, α,β-amyrin greatly suppressed the pancreatic edema, inflammatory cell infiltration, acinar cell necrosis, and expressions of TNFα and inducible nitric oxide synthase.
conclusionsα,β-Amyrin ameliorates cerulein-induced acute pancreatitis by acting as an anti-inflammatory and antioxidant agent.
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