ArticleMolecular biology reports2011
Identification of the ovine KAP11-1 gene (KRTAP11-1) and genetic variation in its coding sequence.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 41 citations in OpenAlex.
- Screening of Protein Related to Wool Development and Fineness in Gansu Alpine Fine-Wool Sheep.Animals : an open access journal from MDPI · 2025Article
- Quantitative Analysis of Hair Luster in a Novel Ultraviolet-Irradiated Mouse Model.International journal of molecular sciences · 2024Article
- The Mechanisms of Fur Development and Color Formation in American Mink Revealed Using Comparative Transcriptomics.Animals : an open access journal from MDPI · 2022Article
- Expression and Variations inGenes · 2022Article
- DNA Methylation Mediates lncRNA2919 Regulation of Hair Follicle Regeneration.International journal of molecular sciences · 2022Article
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- Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus).BMC veterinary research · 2022Article
- The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes.International journal of molecular sciences · 2021Review
- A highly polymorphic caprine keratin-associated protein gene identified and its effect on cashmere traits.Journal of animal science · 2021Article
- Characterization and functional analysis of Krtap11-1 during hair follicle development in Angora rabbits (Oryctolagus cuniculus).Genes & genomics · 2020Article
- Variation in the Caprine Keratin-Associated Protein 27-1 Gene is Associated with Cashmere Fiber Diameter.Genes · 2020Article
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- Identification of Ovine KRTAP28-1 and Its Association with Wool Fibre Diameter.Animals : an open access journal from MDPI · 2019Article
- Variation in the Caprine KAP24-1 Gene Affects Cashmere Fibre Diameter.Animals : an open access journal from MDPI · 2019Article
- Variation inArchives animal breeding · 2019Article
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- Molecular characterization and expression pattern of a novel Keratin-associated protein 11.1 gene in the Liaoning cashmere goat (Asian-Australasian journal of animal sciences · 2017Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratin-associated proteins (KAPs) are a structural component of the wool fibre and form the matrix between the keratin intermediate filaments (KIFs). The gene encoding high sulphur-protein KAP11-1 has been identified in human, cattle and mouse, but not yet in sheep, despite the economic importance of wool. In this study, PCR using primers based on the cattle KAP11-1 gene sequence produced an amplicon of the expected size with sheep DNA. Upon using PCR-Single Stranded Conformational Polymorphism (PCR-SSCP) analysis in 260 sheep, six different PCR-SSCP patterns were detected. Either one or a combination of two banding patterns was observed for each sheep, suggesting they were either homozygous or heterozygous for this gene. Sequencing of the amplicons confirmed the occurrence of six DNA sequences. All of these were unique, and the greatest homology was with KRTAP11-1 sequences from cattle, human and mouse, suggesting that they were derived from the ovine KAP11-1 gene and were allelic variants. The ovine KAP11-1 gene had an open reading frame of 477 nucleotides encoding 159 amino acids. The putative protein was rich in serine, cysteine, and threonine which account for 18.2-18.9, 12.6 and 12.0 mol%, respectively. Of these, approximately 20 of the serine and threonine residues might be phosphorylated. Five nucleotide substitutions were identified, and one was non-synonymous and would result in an amino acid change at a potential phosphorylation site. The genetic variation found in KRTAP11-1 may influence its expression, protein structure, and/or post-translational modifications, and consequently affect wool fibre structure and wool traits.
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