ArticleJournal of the Association for Research in Otolaryngology : JARO2011
Gene expression gradients along the tonotopic axis of the chicken auditory epithelium.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Microvilli control the morphogenesis of the tectorial membrane extracellular matrix.Developmental cell · 2025Article
- 3D reconstruction of the mouse cochlea from scRNA-seq data suggests morphogen-based principles in apex-to-base specification.Developmental cell · 2024Article
- Mitochondrial form and function in hair cells.Hearing research · 2023Review
- Alternative splicing in shaping the molecular landscape of the cochlea.Frontiers in cell and developmental biology · 2023Review
- Position Specific Alternative Splicing and Gene Expression Profiles Along the Tonotopic Axis of Chick Cochlea.Frontiers in molecular biosciences · 2021Article
- Expression and Physiology of Voltage-Gated Sodium Channels in Developing Human Inner Ear.Frontiers in neuroscience · 2021Article
- Calcium-induced calcium release in proximity to hair cell BK channels revealed by PKA activation.Physiological reports · 2020Article
- Differential Gene Expression Patterns Between Apical and Basal Inner Hair Cells Revealed by RNA-Seq.Frontiers in molecular neuroscience · 2019Article
- A novel missense variant in PRKCB segregates low-frequency hearing loss in an autosomal dominant family with Meniere's disease.Human molecular genetics · 2016Article
- Gene expression profiling of the inner ear.Journal of anatomy · 2016Review
- Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Expression and Misexpression of the miR-183 Family in the Developing Hearing Organ of the Chicken.PloS one · 2015Article
- Article
- The evolutionary and genetic origins of consciousness in the Cambrian Period over 500 million years ago.Frontiers in psychology · 2013Article
- Hair cell BK channels interact with RACK1, and PKC increases its expression on the cell surface by indirect phosphorylation.American journal of physiology. Cell physiology · 2012Article
- Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.PloS one · 2012Article
- Gradients and modulation of K(+) channels optimize temporal accuracy in networks of auditory neurons.PLoS computational biology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
There are known differences in the properties of hair cells along the tonotopic axis of the avian auditory epithelium, the basilar papilla (BP). To determine the genetic basis of these differences, we compared gene expression between the high- (HF), middle-, and low-frequency (LF) thirds of 0-day-old chick auditory epithelia. RNA amplified from each sample was hybridized to whole-genome chicken arrays and GeneSpring software was used to identify differentially expressed genes. Two thousand six hundred sixty-three genes were found to be differentially expressed between the HF and LF segments, using a fold-change cutoff of 2 and a p value of 0.05. Many ion channel genes were differentially expressed between the HF and LF regions of the BP, an expression pattern that was previously established for some but not all of these genes. Quantitative PCR was used to verify tonotopic expression of 15 genes, including KCNMA1 (Slo) and its alternatively spliced STREX exon. Gene set enrichment analyses (GSEA) were performed on the microarray data and revealed many microRNA gene sets significantly enriched in the HF relative to the LF end, suggesting a tonotopic activity gradient. GSEA also suggested differential activity of the kinases protein kinase C and protein kinase A at the HF and LF ends, an interesting corollary to the observation that there is tonotopic expression of the STREX exon that confers on Slo sensitivity to the activity of kinases. Taken together, these results suggest mechanisms of induction and maintenance of tonotopicity and enhance our understanding of the complex nature of proximal-distal gene expression gradients in the chicken BP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.