ArticleJournal of molecular evolution2011
Insertion sequence-driven evolution of Escherichia coli in chemostats.
Article in Journal of molecular evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Antisense transcription reveals disease-associated adaptations in the human gut microbiome.Nature microbiology · 2026Article
- Influence of insertion sequences on population structure of phytopathogenic bacteria in theMicrobiology (Reading, England) · 2023Article
- Genomic landscapes of bacterial transposons and their applications in strain improvement.Applied microbiology and biotechnology · 2022Review
- Beyond to the Stable: Role of the Insertion Sequences as Epidemiological Descriptors inFrontiers in microbiology · 2022Article
- The dynamic network of IS30 transposition pathways.PloS one · 2022Article
- Bacterial Adaptation by a Transposition Burst of an Invading IS Element.Genome biology and evolution · 2021Article
- Expanding Characterized Diversity and the Pool of Complete Genome Sequences ofFrontiers in microbiology · 2021Article
- Insertion sequences drive the emergence of a highly adapted human pathogen.Microbial genomics · 2020Article
- Genome rearrangements and megaplasmid loss in the filamentous bacterium Kitasatospora viridifaciens are associated with protoplast formation and regeneration.Antonie van Leeuwenhoek · 2020Article
- Evolutionary Changes after Translational Challenges Imposed by Horizontal Gene Transfer.Genome biology and evolution · 2019Article
- Exploring the rearrangement of sensory intelligence in proteobacteria: insight of Pho regulon.World journal of microbiology & biotechnology · 2018Article
- Instability of the 16S rRNA methyltransferase-encoding npmA gene: why have bacterial cells possessing npmA not spread despite their high and broad resistance to aminoglycosides?The Journal of antibiotics · 2018Article
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- Regulation of solvent tolerance in Pseudomonas putida S12 mediated by mobile elements.Microbial biotechnology · 2017Article
- Transposable Elements Mediate Adaptive Debilitation of Flagella in Experimental Escherichia coli Populations.Journal of molecular evolution · 2017Article
- Environment-directed activation of the Escherichia coliflhDC operon by transposons.Microbiology (Reading, England) · 2017Article
- Dynamics and genetic diversification ofPeerJ · 2017Article
- Quantitative assessment of insertion sequence impact on bacterial genome architecture.Microbial genomics · 2016Article
- Adaptation to Parasites and Costs of Parasite Resistance in Mutator and Nonmutator Bacteria.Molecular biology and evolution · 2016Article
- Dynamics of bacterial insertion sequences: can transposition bursts help the elements persist?BMC evolutionary biology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insertion sequence (IS) elements are present in almost all bacterial genomes and are mobile enough to provide genomic tools to differentiate closely related isolates. They can be used to estimate genetic diversity and identify fitness-enhancing mutations during evolution experiments. Here, we determined the genomic distribution of eight IS elements in 120 genomes sampled from Escherichia coli populations that evolved in glucose- and phosphate-limited chemostats by comparison to the ancestral pattern. No significant differential transposition of the various IS types was detected across the environments. The phylogenies revealed substantial diversity amongst clones sampled from each chemostat, consistent with the phenotypic diversity within populations. Two IS-related changes were common to independent chemostats, suggesting parallel evolution. One of them corresponded to insertions of IS1 elements within rpoS encoding the master regulator of stress conditions. The other parallel event was an IS5-dependent deletion including mutY involved in DNA repair, thereby providing the molecular mechanism of generation of mutator clones in these evolving populations. These deletions occurred in different co-existing genotypes within single populations and were of various sizes. Moreover, differential locations of IS elements combined with their transpositional activity provided evolved clones with different phenotypic landscapes. Therefore, IS elements strongly influenced the evolutionary processes in continuous E. coli cultures by providing a way to modify both the global regulatory network and the mutation rates of evolving cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.