Trial reportAsian journal of andrology2011
Comparison of semen quality and outcome of assisted reproductive techniques in Chinese men with and without hepatitis B.
Trial report in Asian journal of andrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Pooled it
- The association between hepatitis B virus and semen quality: a systematic review and meta-analysis.BMC urology · 2024Pooled it
- The impact of biparental hepatitis B virus infection on pregnancy outcomes in patients undergoing assisted reproductive technology treatment: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2022Pooled it
- Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy.Hepatology international · 2022Guideline
- Effect of hepatitis B virus infection in males on pregnancy outcomes of intrauterine insemination.Scientific reports · 2025Article
- The Effect of Hepatitis B Virus Infection on Semen Quality of Infertile Men: A Systematic Review and Meta-Analysis of Observational Studies.International journal of fertility & sterility · 2024Article
- Hepatitis B virus infection, infertility, and assisted reproduction.Journal of Zhejiang University. Science. B · 2024Review
- Unraveling the Intricacies of the Seminal Microbiome and Its Impact on Human Fertility.Biology · 2024Review
- Assessment of Prior Infection With Hepatitis B Virus and Fecundability in Couples Planning Pregnancy.JAMA network open · 2023Article
- Vertical transmission of hepatitis B virus from father to child: what can be concluded about this possibility?Archives of virology · 2023Review
- An Assessment of Men Semen Alterations in SARS-CoV-2: Is Fever the Principal Concern?Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Human seminal virome: a panel based on recent literature.Basic and clinical andrology · 2022Review
- Viral tropism for the testis and sexual transmission.Frontiers in immunology · 2022Review
- Hepatitis B Surface Antigen Seropositive Men in Serodiscordant Couples: Effects on the Assisted Reproductive Outcomes.The world journal of men's health · 2021Article
- Effect of Hepatitis B Virus Infection on Sperm Quality and Outcomes of Assisted Reproductive Techniques in Infertile Males.Frontiers in medicine · 2021Article
- Impact of hepatitis B virus and hepatitis C virus infection on sperm parameters of infertile men.International journal of reproductive biomedicine · 2019Article
- [Sexually transmitted infections and male fertility].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Review
- Tiaogeng Yijing decoction improves the pregnancy outcomes of patients with poor ovarian response undergoingExperimental and therapeutic medicine · 2017Article
- Prevalence of blood borne viruses in IVF: an audit of a fertility Centre.JBRA assisted reproduction · 2016Article
- The safety of intracytoplasmic sperm injection in men with hepatitis B.Archives of medical science : AMS · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we aimed to determine the effects of hepatitis B virus (HBV) infection on sperm quality and the outcome of assisted reproductive technology (ART). A total of 916 men (457 HBV-positive and 459 HBV-negative) seeking fertility assistance from January 2008 to December 2009 at the Women's Hospital in the School of Medicine at Zhejiang University were analysed for semen parameters. Couples in which the men were hepatitis B surface antigen (HBsAg)-seropositive were categorized as HBV-positive and included 587 in vitro fertilisation (IVF) and 325 intracytoplasmic sperm injection (ICSI) cycles from January 2004 to December 2009; negative controls were matched for female age, date of ova retrieval, ART approach used (IVF or ICSI) and randomized in a ratio of 1:1 according to the ART treatment cycles (587 for IVF and 325 for ICSI). HBV-infected men exhibited lower semen volume, lower total sperm count as well as poor sperm motility and morphology (P < 0.05) when compared to control individuals. Rates of two-pronuclear (2PN) fertilisation, high-grade embryo acquisition, implantation and clinical pregnancy were also lower among HBV-positive patients compared to those of HBV-negative patients after ICSI and embryo transfer (P < 0.05); IVF outcomes were similar between the two groups (P > 0.05). Logistic regression analysis showed that HBV infection independently contributed to increased rates of asthenozoospermia and oligozoospermia/azoospermia (P < 0.05) as well as decreased rates of implantation and clinical pregnancy in ICSI cycles (P < 0.05). Our results suggest that HBV infection in men is associated with poor sperm quality and worse ICSI and embryo transfer outcomes but does not affect the outcome of IVF and embryo transfer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.