Evidence map›Paper›PMID 21399271›Full record

ReviewJournal of physics. Condensed matter : an Institute of Physics journal2010

Computational approaches to 3D modeling of RNA.

Christian Laing, Tamar Schlick

Abstract readComparative StudyReview
In one paragraph

Review in Journal of physics. Condensed matter : an Institute of Physics journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. RNA 3D Structure Prediction: Progress and Perspective.Molecules (Basel, Switzerland) · 2023
    Review
  7. Nucleic acid nanostructures forApplied physics reviews · 2023
    Review
  8. Article
  9. RNAloops: a database of RNA multiloops.Bioinformatics (Oxford, England) · 2022
    Article
  10. Article
  11. Article
  12. IsRNA1:Journal of chemical theory and computation · 2021
    Article
  13. A Fiedler Vector Scoring Approach for Novel RNA Motif Selection.The journal of physical chemistry. B · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Adventures with RNA graphs.Methods (San Diego, Calif.) · 2018
    Review
  18. Article
  19. Molecular chaperones maximize the native state yield on biological times by driving substrates out of equilibrium.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christian LaingDepartment of Chemistry and Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY 10012, USA.
Tamar Schlick

Funding

Modeling Chromatin Organization and FunctionR01GM055164 · NIGMS · NEW YORK UNIVERSITY · PI SCHLICK, TAMAR · 1998 to 2015
$2.6M
Computational studies of in vitro selection of RNAsR01GM081410 · NIGMS · NEW YORK UNIVERSITY · PI SCHLICK, TAMAR · 2009 to 2012
$1.2M
Mechanisms of DNA PolymerasesR01ES012692 · NIEHS · NEW YORK UNIVERSITY · PI SCHLICK, TAMAR · 2005 to 2007
$843k
NIEHS NIH HHS 1 R01 ES 012692NIEHS NIH HHS R01 ES012692NIGMS NIH HHS R01 GM055164NIGMS NIH HHS R01-GM055164NIGMS NIH HHS R01 GM081410
6 · The paper itself

Abstract

Many exciting discoveries have recently revealed the versatility of RNA and its importance in a variety of functions within the cell. Since the structural features of RNA are of major importance to their biological function, there is much interest in predicting RNA structure, either in free form or in interaction with various ligands, including proteins, metabolites and other molecules. In recent years, an increasing number of researchers have developed novel RNA algorithms for predicting RNA secondary and tertiary structures. In this review, we describe current experimental and computational advances and discuss recent ideas that are transforming the traditional view of RNA folding. To evaluate the performance of the most recent RNA 3D folding algorithms, we provide a comparative study in order to test the performance of available 3D structure prediction algorithms for an RNA data set of 43 structures of various lengths and motifs. We find that the algorithms vary widely in terms of prediction quality across different RNA lengths and topologies; most predictions have very large root mean square deviations from the experimental structure. We conclude by outlining some suggestions for future RNA folding research.

Indexed as

Models, ChemicalModels, MolecularComputer SimulationNucleic Acid ConformationNucleic Acid DenaturationProtein ConformationRNARNA

Identifiers

PMID21399271
PMCPMC6286080

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.