ArticleJournal of virology1990
cis-dominant defect in activation of adenovirus type 5 E1b early RNA synthesis.
Article in Journal of virology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Strong foreign promoters contribute to innate inflammatory responses induced by adenovirus transducing vectors.Virology · 2011Article
- Article
- E1A and E1B proteins inhibit inflammation induced by adenovirus.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Local character of readthrough activation in adenovirus type 5 early region 1 transcription control.Journal of virology · 2003Article
- Readthrough activation of early adenovirus E1b gene transcription.Journal of virology · 1997Article
- A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.Journal of virology · 1997Article
- The adenovirus E1A transforming protein activates the proliferating cell nuclear antigen promoter via an activating transcription factor site.Journal of virology · 1991Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
A cis-dominant mutation in the adjacent E1a gene disrupted the accumulation of adenovirus type 5 E1b mRNA during the early phase of infection. Steady-state levels of cytoplasmic and nuclear E1b RNAs in cells infected with dl312, a strain that lacks the E1a TATA box, cap site, and much of the coding sequence, were reduced 5- to 10-fold even when the E1a activator was provided in trans. The strain was defective for early E1b RNA synthesis but not for E1b RNA made late or during prolonged incubation in the presence of an inhibitor of DNA replication. The defect in E1b RNA synthesis could not be attributed to the E1a promoter sequences missing in dl312 DNA. If the E1a protein-coding region contains cis-acting regulatory sequences, they are not part of the previously mapped E1b transcriptional control region and may represent additional regulatory elements that ensure prompt and efficient E1b expression during the early phase of infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.