ArticleNucleic acids research2011
Alternative splicing and genetic diversity: silencers are more frequently modified by SNVs associated with alternative exon/intron borders.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Population-level exploration of alternative splicing and its unique role in controlling agronomic traits of rice.The Plant cell · 2024Article
- Article
- Revisiting the identification of canonical splice isoforms through integration of functional genomics and proteomics evidence.Proteomics · 2014Article
- Testing for natural selection in human exonic splicing regulators associated with evolutionary rate shifts.Journal of molecular evolution · 2013Article
- The relationship between gene isoform multiplicity, number of exons and protein divergence.PloS one · 2013Article
- Systematically differentiating functions for alternatively spliced isoforms through integrating RNA-seq data.PLoS computational biology · 2013Article
- SPLOOCE: a new portal for the analysis of human splicing variants.RNA biology · 2012Article
- Article
- Genetic variations and alternative splicing: the Glioma associated oncogene 1, GLI1.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the availability of a large amount of genomic data it is expected that the influence of single nucleotide variations (SNVs) in many biological phenomena will be elucidated. Here, we approached the problem of how SNVs affect alternative splicing. First, we observed that SNVs and exonic splicing regulators (ESRs) independently show a biased distribution in alternative exons. More importantly, SNVs map more frequently in ESRs located in alternative exons than in ESRs located in constitutive exons. By looking at SNVs associated with alternative exon/intron borders (by their common presence in the same cDNA molecule), we observed that a specific type of ESR, the exonic splicing silencers (ESSs), are more frequently modified by SNVs. Our results establish a clear association between genetic diversity and alternative splicing involving ESSs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.