ArticleThe Plant cell2011
Transcriptome and metabolite profiling show that APETALA2a is a major regulator of tomato fruit ripening.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers.
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Who cites it
181 citing papers in PubMed.
- The regulatory role of DzERF94 in carotenoid biosynthesis during ripening in durian (Durio zibethinus) pulp.Plant cell reports · 2026Article
- Cultivar-Dependent Biosynthesis, Sustainable Recovery, and Industrial Applications of Tomato-Derived Carotenoids.Plants (Basel, Switzerland) · 2026Review
- Light regulates tomato fruit metabolome via SlDML2-mediated global DNA demethylation.Journal of integrative plant biology · 2026Article
- Transcriptional control of tomato fruit development and ripening.Journal of experimental botany · 2025Review
- What metabolomics has taught us about tomato fruit ripening and quality.Journal of experimental botany · 2025Review
- Overexpression ofPlants (Basel, Switzerland) · 2025Article
- Allelic value in gene regulation-implications for gene editing.Annals of botany · 2025Article
- Slow and steady wins the race: the negative regulators of ethylene biosynthesis in horticultural plants.Horticulture research · 2025Article
- SlPLT6 controls ripening initiation and quality traits through modulation of histone acetylation and methylation in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Two transcription factors play critical roles in mediating epigenetic regulation of fruit ripening in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Molecular regulation and domestication of parthenocarpy in cucumber.Nature plants · 2025Article
- Transcriptomic and metabolomic analysis of carotenoid metabolism and accumulation of carotenoid-derived products in tobacco leaves before and after curing.Frontiers in plant science · 2025Article
- Article
- Transcriptomics in solanaceous crop improvement: advances and opportunities.Frontiers in plant science · 2025Review
- Chlorophyll and Carotenoid Metabolism Varies with Growth Temperatures among Tea Genotypes with Different Leaf Colors inInternational journal of molecular sciences · 2024Article
- Ethylene in fruits: beyond ripening control.Horticulture research · 2024Article
- The underlying molecular mechanisms of hormonal regulation of fruit color in fruit-bearing plants.Plant molecular biology · 2024Review
- JOINTLESS Maintains Inflorescence Meristem Identity in Tomato.Plant & cell physiology · 2024Article
- Integrative analysis of the methylome and transcriptome of tomato fruit (Horticulture research · 2024Article
121 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
Fruit ripening in tomato (Solanum lycopersicum) requires the coordination of both developmental cues as well as the plant hormone ethylene. Although the role of ethylene in mediating climacteric ripening has been established, knowledge regarding the developmental regulators that modulate the involvement of ethylene in tomato fruit ripening is still lacking. Here, we show that the tomato APETALA2a (AP2a) transcription factor regulates fruit ripening via regulation of ethylene biosynthesis and signaling. RNA interference (RNAi)-mediated repression of AP2a resulted in alterations in fruit shape, orange ripe fruits, and altered carotenoid accumulation. Microarray expression analyses of the ripe AP2 RNAi fruits showed altered expression of genes involved in various metabolic pathways, such as the phenylpropanoid and carotenoid pathways, as well as in hormone synthesis and perception. Genes involved in chromoplast differentiation and other ripening-associated processes were also differentially expressed, but softening and ethylene biosynthesis occurred in the transgenic plants. Ripening regulators RIPENING-INHIBITOR, NON-RIPENING, and COLORLESS NON-RIPENING (CNR) function upstream of AP2a and positively regulate its expression. In the pericarp of AP2 RNAi fruits, mRNA levels of CNR were elevated, indicating that AP2a and CNR are part of a negative feedback loop in the regulation of ripening. Moreover, we demonstrated that CNR binds to the promoter of AP2a in vitro.
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